dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000590
Uniprot Accession O14176; PRP40_SCHPO;
Genbank Protein ID NP_594966.1;
Genbank Nucleotide ID NM_001020397.2;
Protein Name Pre-mRNA-processing protein prp40
Protein Synonyms/Alias
Gene Name prp40
Gene Synonyms/Alias SPAC4D7.13;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity).
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
688NIVDDAESSEEGEIRdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
689IVDDAESSEEGEIR-dbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
Sequence
(Fasta)
MSAPPWQTSE YDETEGFTSN QEGPSAAPSK TVASDWHEVK TEDSRVYYYN SVTRKSVWEK 60
PEELMNDFEK KLSKLAWKEY ATADGKKYWY NVNTRESVWD IPDEYKAALV DEPEQQKKAL 120
SSKIKSNDNK PAVQSIQRHG PDVAAPSSQP AKDQSQQISQ GSHKRTINFV QQKDKRQKRS 180
NDYQHENYDT YEAAERAFFK FLDSHNVNPS WTWEQTVREL CDAKGYYVMK DPWHRKCAFD 240
AYILNYLTDQ SDAEKNRVTK IRKEFIEMLK SSDKIHSYTL WRTVKNEFSS HPAFNATSSE 300
TEQQQLFFEY KQKLLEDEKQ LEKDRRKEAL DDFCSLLRNM NFEPYTRWSV AQAKFDQDPR 360
YTRNSNMKYL SKLDALVAFE DHVKHLEREY ILDKQKQKKE KHRIERKNRD AFRALLQDLR 420
VQKKITLRTK WKELYPIIKD DPRYLNLLGQ SGSTPLDLFW DTIVDLENMY REKRNLVLDC 480
LEVLQISVDD TSNIPEIIAR LSEKLKDREE SEAVTEDLIE EVVNRLRDKA IHKKAEEKRA 540
DERRIRRKID NLRSAIKYLK PPISADASYD EIRPLISILP EFAALHSEEH RMAAFDKYIR 600
RLREKRELEK QYQNRRGYYD VGKDESYLAN SARPHSGYED GRLEYSADLA SKSNRNEINT 660
MQDVQENSIS HVTATQPAVK NIVDDAESSE EGEIR 696
Keyword

KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein

Interpro

IPR002713--FF_domain
IPR001202--WW_dom

PROSITE

PS51676--FF
PS50020--WW_DOMAIN_2

Pfam

PF01846--FF
PF00397--WW

Gene Ontology

GO:0000243--C:commitment complex
GO:0005634--C:nucleus
GO:0005685--C:U1 snRNP
GO:0071004--C:U2-type prespliceosome
GO:0003723--F:RNA binding
GO:0000395--P:mRNA 5'-splice site recognition
GO:0045292--P:mRNA cis splicing, via spliceosome