dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000589
Uniprot Accession O14164; EIF3C_SCHPO; O13885; P78791; Q9P6P4;
Genbank Protein ID NP_593828.2;
Genbank Nucleotide ID NM_001019257.2;
Protein Name Eukaryotic translation initiation factor 3 subunit C
Protein Synonyms/Alias
Gene Name nip1
Gene Synonyms/Alias eif3c;tif33;SPAC1E11.01c;SPAC4A8.16c;SPAC823.01c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
10RFFKGGSSDSDAESVdbPTM 3.018257517; 16381945; 23193290
12FKGGSSDSDAESVDSdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
16SSDSDAESVDSSEENdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
19SDAESVDSSEENRLTdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
20DAESVDSSEENRLTSdbPTM 3.018257517; 16381945; 23193290
132ESDESERSGPSSFLKdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
667APKFGQFTPDQDRLDdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MSRFFKGGSS DSDAESVDSS EENRLTSSRL KKQDDSSSEE ESSEEESASS SESESSEEES 60
ESEESEVEVP KKKAVAASED SESDSESSEE EEETESEEDS EVSDESESES ESESESEEES 120
ESEEESDESE RSGPSSFLKK PEKEEAKPAG LKFLRGESSE ESSDEEEGRR VVKSAKDKRY 180
EEFISCMETI KNAMSSNNWI VVSNEFDHLN KVSQKCKEAG RNPPPYIEFL SALDQKLESA 240
DKAFIKSLDA ANGRAFNALK QRVRKNNRQF QSDIDRYRKD PEGFMKPAEL NEIPKPAGKA 300
GQDEVIVDGV ATRGIVAPTE GLGKPEEITP ADIFKYLRAI FEARGKKSTD RSEQIRLLEK 360
LSTIAVTDYQ RLRVKVALLA VRFDINTGSG QYMPIDQWNA ALTELHSILD IFDANPKIVI 420
VEQVEDENEE EEEAIAAAEN NNGVIQVQGS VVSFLERLDD EFTRSLQMID PHTPEYIDRL 480
KDETSLYTLL VRSQGYLERI GVVENTARLI MRRLDRVYYK PEQVIRANEE VAWRSFPPTF 540
DLTITPRATT TTPDILIHSL CVYLYNNGVS LLRTRAMLCH IYHEALQNRF YKARDMLLMS 600
HLQDSVHAAD IATQILHNRT MVQIGLCAFR NGMVQETQYA LQDISTTGRV KELLGQGIQA 660
PKFGQFTPDQ DRLDKQLVLP FHMHINLELL ECVYLTCSML MEIPAMAAAS STASDSRKRV 720
ISRPFRRMLE YIDRQLFVGP PENTREYIMQ ASKALADGEW RRCEEFIHAI KIWSLMPDAD 780
KIKQMLSEKI REEGLRTYLL AYAAFYDSVS LEFLATTFDL PVQRVTVIVS RLLSKREIHA 840
ALDQVHGAII FERVEINKLE SLTVSLSEKT AQLNEANEKL YEQKTQHTNP QENRRRDKGG 900
SVKRRNERTE NRNRSDMN 919
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
Interpro

IPR027516--EIF3C
IPR008905--EIF3C_N_dom
IPR000717--PCI_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF05470--eIF-3c_N
PF01399--PCI
Gene Ontology

GO:0005829--C:cytosol
GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071540--C:eukaryotic translation initiation factor 3 complex, eIF3e
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0003743--F:translation initiation factor activity
GO:0001732--P:formation of cytoplasmic translation initiation complex
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation