dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000588
Uniprot Accession O14161; CWC21_SCHPO; Q9UT69;
Genbank Protein ID NP_593820.1;
Genbank Nucleotide ID NM_001019250.2;
Protein Name Pre-mRNA-splicing factor cwf21
Protein Synonyms/Alias Complexed with cdc5 protein 21;
Gene Name cwf21
Gene Synonyms/Alias SPAC4A8.09c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
118QSQSKTKSLDEADVEdbPTM 3.0;UniProt18257517; 16381945; 23193290
285IPVVDRDSSPEGGEIdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
286PVVDRDSSPEGGEIVdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MSYNGIGLPT PRGSGTNGYV MRNLSHVKKY DKNTNLQSNR NAKALEKRVQ DPSISEHECR 60
RQIESKLLLY REQLLEEVSS QHSTDAAASD SNTNFGTENP KPPKAIIKDE QSQSKTKSLD 120
EADVEILVQK YREQLLKELQ LQKSTEKGKN FESILQPQKR KETRGFHSKN DDDGRLEERD 180
DLRSSVDDDY YDYPRYSERK SLNSKRHVDN YNENRRRHYD SYSSYDELER RRSSNESYSR 240
RSELPRRDYN RHDERERYSY HRRRERSNSP SYTKNESIPV VDRDSSPEGG EIV 294
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome

Interpro

IPR013170--mRNA_splic_Cwf21_dom

PROSITE
Pfam

PF08312--cwf21

Gene Ontology

GO:0005737--C:cytoplasm
GO:0044732--C:mitotic spindle pole body
GO:0005634--C:nucleus
GO:0005684--C:U2-type spliceosomal complex
GO:0045292--P:mRNA cis splicing, via spliceosome