dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000586
Uniprot Accession O14148; INO80_SCHPO; O14025;
Genbank Protein ID NP_001018299.1;
Genbank Nucleotide ID NM_001020410.2;
Protein Name Putative DNA helicase ino80
Protein Synonyms/Alias
Gene Name ino80
Gene Synonyms/Alias SPAC29B12.01;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
DNA helicase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
179VPRPDANTVSPHAARdbPTM 3.0;UniProt18257517; 16381945; 23193290
272LPPAQKLSPNSSQSQcurated22817900
518LQSAGVASDGESSPEdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
771VSEINFDSDEEEDIRdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MDPSRETFDG STRDSYKPPN GAEMMGQSEL NTQNRIPYNT SANNRNWQIP LYWQQRGNEF 60
QASPPPPLGY VTPEYGATGT PVNANNASRV DYATTAANVP EEYANDYSSE LAYIHNVNDM 120
PHVDGLSNHS PATQPDLFET PAQSDPILFS SYPHAAQARV DPSISKDLYN MVPRPDANTV 180
SPHAARSASS LPVPKEASET PFRDASTDLF DEHAHAAPMH SSISISTLLS DSDRYEPHVS 240
LTENISPVMA PSIDARLSQT ILRGLPPAQK LSPNSSQSQI THNRRKHKLP LNATTNNSVV 300
LTPDTSPLLD SDEVVSDDDS NEQQTMMMKF NYLQHLRNKR DEAVHAEKRR LLDIRGSIHD 360
RLVCRYENRY NKLHASEYNH HHDWAVRQAI REEVAAVEAA KIRADEEKKK KEREEQVRLL 420
QESADKDAEM NEASTATSEN EDLKDDLSLA DLSSKKTANS QATENNNTPS KAKVKAESKV 480
RSKAKSDKSR AKLSSDTNKD SEKNDNNDAS LQSAGVASDG ESSPETPLTK ASKSKKAKAS 540
KLANDTSKNA NGETKSTPKK SKKKTSKAQQ EANSTTAEGK EKLSGDSTET GNSTNKEAST 600
EDTKANATAS APNKKKKTVE TLQQQVIKEI ARKEIPRVYK IIQQNQYNRS TNARKTSQLC 660
GREARRWQFR TIKNNKDMQT KAKRAMRETM VFWKRNERVE RDLRKKAERE ALDRAKKEEE 720
LRESRRQARK LDFLITQTEL YSHFVGRKMD REQDLPSATN TASVSEINFD SDEEEDIRRL 780
AVESAQEAVQ KAREHSQLFD ANRQQSPNNS SSDMNEGEMN FQNPTLVNAF EVKQPKMLMC 840
KLKEYQLKGL NWLANLYEQG INGILADEMG LGKTVQSISV MAYLAETHNI WGPFLVIAPA 900
STLHNWQQEI TRFVPKLKCI PYWGSTKDRK ILRKFWCRKN MTYDENSPFH VVVTSYQLVV 960
LDAQYFQSVK WQYMILDEAQ AIKSSSSSRW KSLLAFKCRN RLLLTGTPIQ NTMQELWALL 1020
HFIMPSLFDS HNEFSEWFSK DIESHAQSNT QLNEQQLKRL HMILKPFMLR RVKKNVQSEL 1080
GEKIEKEVYC DLTQRQKILY QALRRQISIA ELLEKAILGG DDTVASIMNL VMQFRKVCNH 1140
PDLFEREDVR SPLSLATWSK SIYINREGNF LDVPYNTRNF ITFSIPRLLY EQGGILSVPG 1200
LNTSRGFETK YLYNLMNIWN PEYTNDSIKS NPEGSPFSWL RFVDESPQTL FQTFQNPVVH 1260
YLDEAEASSS LKEEQLCRQE FCYGKDYSNV RKMLLLPKSI TKVDVLGSDF KEDSPFYHLT 1320
HVLEESDSQL DLTLLDSVLV QRASAPPIDI YCPGSRQFTV LQSRFQRDHL WSHYLYQPLK 1380
GEEDLIINNQ AVSKLPIPRK PLLPSFGIAK GSYSNVRIPS MLRFIADSGK LSKLDKLLVE 1440
LKANDHRVLI YFQMTRMIDL MEEYLTFRQY KYLRLDGSSK ISQRRDMVTE WQTRPELFVF 1500
LLSTRAGGLG INLTAADTVI FYDSDWNPSI DSQAMDRAHR IGQQKQVTVY RFITRGTIEE 1560
RIVIRAKEKE EVQKVVISGG ETRPTKQMDL KGNSREMVSW LLEE 1605
Keyword

KW-0010--Activator
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR020838--DBINO
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N

PROSITE

PS51413--DBINO
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER

Pfam

PF13892--DBINO
PF00271--Helicase_C
PF00176--SNF2_N

Gene Ontology

GO:0031011--C:Ino80 complex
GO:0005524--F:ATP binding
GO:0043140--F:ATP-dependent 3'-5' DNA helicase activity
GO:0003677--F:DNA binding
GO:0016568--P:chromatin modification
GO:0032508--P:DNA duplex unwinding
GO:0006281--P:DNA repair
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated