| Tag |
Content |
| dbPAF ID |
dbPAF-0000572 |
| Uniprot Accession |
O14098; CTK1_SCHPO;
|
| Genbank Protein ID |
NP_594393.1;
|
| Genbank Nucleotide ID |
NM_001019816.2;
|
| Protein Name |
CTD kinase subunit alpha |
| Protein Synonyms/Alias |
|
| Gene Name |
lsk1 |
| Gene Synonyms/Alias |
ctk1;SPAC2F3.15; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in response to perturbation of the actomyosin ring. Acts in parallel to clp1 to promote actomyosin ring stability upon cytokinesis checkpoint activation.Functional Description
Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in response to perturbation of the actomyosin ring. Acts in parallel to clp1 to promote actomyosin ring stability upon cytokinesis checkpoint activation. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MSYSKSTIYR RQGTEPNSHF RRTVEEKSQL SGTNEESLGG HTLSSNAFKN NSSSISPSSS 60
AKDPREQRKR TFPLNDTHSS RARQHERPFR SRKSRRRKGK KAFSPRPGSP PSPSFYRSGS 120
QKRARNLTTK DYFAKRSESS SSASVSPISP SANRNDSKRQ ASSFRRSPPS SVHMKPSAFN 180
GRKVSRRPSS SPPPIPSIPH ETTSSDTQKK SSVSSGFPEN KHGKFHFHIP NERRSRFDQP 240
PSKRMALTST ARESVPAPLP SPPSGPIYTY TYPKPAYEKI DQIGEGTYGK VYKAINTVTG 300
DLVALKRIRL EQEKDGFPIT TVREVKILQR LRHKNIVRLL EIMVEKSSVY MVFEYMDHDL 360
TGVLLNSQLH FTPGNIKHLS KQIFEALAYL HHRGVLHRDI KGSNILLNNN GDLKFADFGL 420
ARFNTSSKSA NYTNRVITLW FRPPELLLGE TAYDTAVDIW SAGCIVMELF TGKPFFQGRD 480
EISQLEVIYD MMGTPDVHSW PEVKNLPWYE LLKPVEEKKS RFVETFKEIL SPAAIDLCQK 540
LLALNPFCRP SAHETLMHEY FTSESPPPEP AVILKNMQGS WHEWESKKRK SKR
594Fasta Sequence
>O14098|lsk1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MSYSKSTIYRRQGTEPNSHFRRTVEEKSQLSGTNEESLGGHTLSSNAFKNNSSSISPSSSAKDPREQRKRTFPLNDTHSSRARQHERPFRSRKSRRRKGKKAFSPRPGSPPSPSFYRSGSQKRARNLTTKDYFAKRSESSSSASVSPISPSANRNDSKRQASSFRRSPPSSVHMKPSAFNGRKVSRRPSSSPPPIPSIPHETTSSDTQKKSSVSSGFPENKHGKFHFHIPNERRSRFDQPPSKRMALTSTARESVPAPLPSPPSGPIYTYTYPKPAYEKIDQIGEGTYGKVYKAINTVTGDLVALKRIRLEQEKDGFPITTVREVKILQRLRHKNIVRLLEIMVEKSSVYMVFEYMDHDLTGVLLNSQLHFTPGNIKHLSKQIFEALAYLHHRGVLHRDIKGSNILLNNNGDLKFADFGLARFNTSSKSANYTNRVITLWFRPPELLLGETAYDTAVDIWSAGCIVMELFTGKPFFQGRDEISQLEVIYDMMGTPDVHSWPEVKNLPWYELLKPVEEKKSRFVETFKEILSPAAIDLCQKLLALNPFCRPSAHETLMHEYFTSESPPPEPAVILKNMQGSWHEWESKKRKSKR
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0507--mRNA processing
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0804--Transcription
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0008024--C:positive transcription elongation factor complex b
GO:0005524--F:ATP binding
GO:0097472--F:cyclin-dependent protein kinase activity
GO:0008353--F:RNA polymerase II carboxy-terminal domain kinase activity
GO:1902406--P:mitotic actomyosin contractile ring maintenance
GO:0006397--P:mRNA processing
GO:0071619--P:phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
GO:0031031--P:positive regulation of septation initiation signaling
GO:0006351--P:transcription, DNA-templated
|
