dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000564
Uniprot Accession O14072; ATC4_SCHPO; Q9USD0; Q9UT01;
Genbank Protein ID NP_593971.1;
Genbank Nucleotide ID NM_001019398.2;
Protein Name Manganese-transporting ATPase 4
Protein Synonyms/Alias
Gene Name cta4
Gene Synonyms/Alias SPAC2E11.07c;SPACUNK4.07c;SPAPYUK71.01;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity). Involved in controlling nuclear calcium ion levels. Required for cytokinesis and stabilizing microtubules.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
948FDTLANASDDEAPKLdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MGSKALITSP DISSGQLYIK LPTFFHLYVW PFALFVYPYI GYVYQNKLYS EEVRYLTYIA 60
VGTIHALFWL AGEWNTKVYC LMTCRKTDKV EQATHILVTP SKIGESSSVE PITKLVLPDS 120
QTIQYSFSFQ RKRFIYEPEK GCFANITFPM DEPSTIGTLK KSTGLTNIQS EIFLYRYGKN 180
CFDIPIPTFG TLFKEHAVAP FFVFQIFCCV LWCLDDYWYF SLFSMFMIIA LECSVVWQRQ 240
RTLTEFRTMS IKPYEIQVYR NKHWFPISTE DLLPNDVVSV LHNKEDSGLP CDLLLLSGSC 300
VVNEAMLSGE STPLVKESIE LRPEEAVIDV DELDKNAVLF GGTRVLQVTQ SPFCKLKTPD 360
NGVPAIVLRT GFETSQGSLV RTMVFSSEKV TANNRESLYF ILFLLVFAIA ASGYVWHVGS 420
KTERSRYKLM LDCVMIITSV VPSELPMELS MAVNASLGAL SKYYIYCTEP FRIPLSGHLD 480
ICCFDKTGTL TEEHMVVQGI AGVNRKDPYS LEKLSDASND AILAIATAHT LVLLEQEGET 540
PKVVGDPMEK ATVENLGWSI EKKNFVSAPE GSVFYKGKVQ IIRNFQFSSA LKRQSSVSNV 600
RVSGGSFKTF VSVKGAPEVI ATMLREVPKD YEKIYKDYGR KGSRVLALGY KYFKNYIPEN 660
QVSDLSRESI ESDLVFAGFL IFTSPLKEDA RQTVQMLNNS SHRCMMITGD NPLTAVYVAE 720
QVGIVEKPTL VLDIKHENEK ILEWKSTDDT INLPMNPHKS LEASLYEKYD LCITGRALSQ 780
IINPDVIMSI FTHAWVYARV SPSQKEFMIS TLKHNGYITL MCGDGTNDVG ALKQAHVGVA 840
LLNASEEDML EMQERARNQK LMGVYEKQIQ LAKRFNLPTP PVPPALCHAF PPGPNNPHRE 900
KTQEGLNKVL EDLETKKASD VQLTEAEKAA ERRANLANKM FDTLANASDD EAPKLKLGDA 960
SVAAPFTSKL AVVSSITNIV RQGRCTLVAL VQMHKILALN CLITAYSLSV LHLDGIKFGD 1020
TQYTISGMLM SVCFYCVSRA RPLETLSKER PQAGIFNTYI IGSVLGQFAI HIVTLIYITR 1080
VVYLYEDPLE KVDLEETFKP SLLNTAIYLL QLIQQVSTFA INYQGRPFRE ALSENKGMYY 1140
GLLGIAFVAI AGVTEFSPEL NAKLQLVKMA YNFQIQLLAT MVVDYAACWI IEELMKKYFR 1200
DNKPKEIVLR N 1212
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport

Interpro

IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR006544--P-type_TPase_V
IPR001757--P_typ_ATPase

PROSITE

PS00154--ATPASE_E1_E2

Pfam

PF00122--E1-E2_ATPase

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0046872--F:metal ion binding
GO:0070588--P:calcium ion transmembrane transport
GO:0006874--P:cellular calcium ion homeostasis