dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000562
Uniprot Accession O14066; IRS4_SCHPO; Q9UQW4;
Genbank Protein ID NP_593127.1;
Genbank Nucleotide ID NM_001018523.2;
Protein Name Increased rDNA silencing protein 4 homolog
Protein Synonyms/Alias
Gene Name SPAC1687.09
Gene Synonyms/Alias
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
1028VSLPHRHSVSLGQIRcurated22817900
Sequence
(Fasta)
MDAIHPVSLR NSKRHPLLHS ERNLSRRAVS PSISRSFFQH SNGSFPLFQN HRKSLPSAIY 60
KSVDPYVDAN PLDPLAAAKA SFADFPEQDD SQSSTSPLSS KYHTKKNKQI FVEDSRRGGA 120
ASNAAAIAAK KSGYYERTST RKRSLTVPTP RTSFPHHPRS RRFSLKNAAI ATSYHKFKPL 180
SSNSLSSSGM HFSASKQAFN SPLLQTFSPS PSVSPFSNPA VEKLKTSASK QAAEAQSLRE 240
FDFFTPTPEP SDKNLEKLKN GASKQASESQ SLKNMESLSL ARSSPILTSE KLKNGASKQA 300
IESPPFRASE PLPSSNIIPN PAMERLKNGA SKLAIESQPF KSAEPLSSAI PLPNPMSEKM 360
RNGASKQAIM AQSSKINPLP PLTASISDPS FEKLKNTASK QAIESQSLMN SGPELLEPSI 420
SDPMLEKMKT DAGKQTVESL SLKSSDATIP KPSVSDLGVE KLKNDASKCA VESQSLMIND 480
PSVSSTSFYN PNMEKLKNGA IKQAIEHQAL NAAILNKTQL PYFHQSSSEL PISASKRAAL 540
SQQTESASKS SSNISEMCDS HPPSNFSISA SQQASKDRFS EATSSIDLDL SPGRSLSLAS 600
SKLSVKEAGA RVYNRSVATP VMTPSNPFEI SKSASQLASI AQVPVSEPAK TSEVNLKKSL 660
SLASSKLSFQ EAGTSLKEKT ANVQHSPEVL NDRSLASLSA SRHADAISSK SKQHTEIAQP 720
AFNTTGTVLM KTKSNLSDSA LSTPQHSDSV LFDITSKAAR LASTCAKTDL HRKPRRKHKS 780
FTLENYFGHN AEDESPQSDE VESQTPPSGY SENDIGGTDI YPFALQGAAL AAAKDFSRRE 840
ASLSDSQSAA SMDMLPMKKK LSHSSASSTR SIKSLLTNAN QKHIHSSINE TDDIPTMAAH 900
IVATGQKNKE KAPSFSNDQA LDHLLGSAHK RIPSNKTEWS SSSLHIPSHN SFSDIHHRKI 960
AAHAAAITAA SEKLTPSIEE TSYSSSKAHD ASLSAATLVA NKDKLIHAPT PQVLAPVLPK 1020
VSLPHRHSVS LGQIRGESEV EGDVFYDAPS DKEDLGSSNA PLDVPHGANR SSMDEVNGSK 1080
YDYSDGILDG SGQYTDSDMS DDENSLKDSQ SSVLSFSAVP TKVLKFKLRD VLGSEYSPSP 1140
QLLASSSDVS GSSSAVRAAM KADKIFPAVH ENPPPLKTKQ SIAKPSPHTL RVPQKKHKHF 1200
YHRDDGKYKS GTNLRKSETV DLPQFFIDEN RRKLYEGLWA ANKGYLLSKS EYSKPNDLIC 1260
NIVVRELWSR SGAPTSVLAK IYDLVDRHHT GVLGRDEFIV GMFLIDQYLK GRKLPLKVPD 1320
SVWLSSKRMG DMLWRLEKLQ KKTDNKKPFF KKKKKKRKHL KKFFDFNTTA KVNEGAMTD 1380
Keyword

KW-0181--Complete proteome
KW-0443--Lipid metabolism
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR000261--EH_dom

PROSITE

PS50222--EF_HAND_2
PS50031--EH

Pfam
Gene Ontology

GO:0032153--C:cell division site
GO:0051286--C:cell tip
GO:0005829--C:cytosol
GO:0072686--C:mitotic spindle
GO:0044732--C:mitotic spindle pole body
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0000407--C:pre-autophagosomal structure
GO:0005509--F:calcium ion binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0006914--P:autophagy
GO:0032258--P:CVT pathway
GO:0048017--P:inositol lipid-mediated signaling
GO:0006629--P:lipid metabolic process
GO:0048015--P:phosphatidylinositol-mediated signaling