| Tag |
Content |
| dbPAF ID |
dbPAF-0000560 |
| Uniprot Accession |
O14064; BIR1_SCHPO; Q9USG4; Q9UTZ0;
|
| Genbank Protein ID |
NP_587866.3;
|
| Genbank Nucleotide ID |
NM_001022859.3;
|
| Protein Name |
Protein bir1 |
| Protein Synonyms/Alias |
Chromosome segregation protein cut17; |
| Gene Name |
bir1 |
| Gene Synonyms/Alias |
cut17;pbh1;SPCC962.02c;SPCP31B10.10c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3.Functional Description
Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MKPITSSSKR RWNRFRREMC NYSKRLDTFQ KKKWPRAKPT PETLATVGFY YNPISESNSE 60
ERLDNVTCYM CTKSFYDWED DDDPLKEHIT HSPSCPWAYI LSSKNNPNQN PQAAALTKCR 120
EQTFVDKVWP YTNRPDYHCE PSVMAASGFV YNPTADAKDA AHCLYCDINL HDWEPDDDPY 180
TEHKRRRADC VFFTWKDPNS LSPTKLSFLS TSNIDPEDLT EDNSILPVSP TRDSTKSHKT 240
LNFSPSRKNN LNARPLTMSL YTNTSEEKDS QPTRAPQSPT KPVLLTAPRR KNKSPKKSKP 300
AVFKPVKPIF SDEDEDDDDL TASQPFSKGI CNDSMQVAKK NFTEEIPLKE DEKDNELEHL 360
VSPATSVHTT VSDITGHQSV TDESDEQNNC MSTPPKIEIE SKIEEEISVV SKSKEISSSV 420
SSVGKEQNHT EKQVAIETPE QQKVEKEDEH LNLQGSFIEE STKQPISSKP STSSPDMTDA 480
ATGGRVSSSS FRDKILQTNF SPRSTIDSFS NISKKRNSEE ANDENDETNL KIPIPEKKRK 540
FQEVLQSKNI LVSSTEDSHE PVKVTEDSQT AIHVSKFEDL ENKSMESEQS LQLLSESEND 600
DKPLIDLIPL LAIKRKDNLV SGVLEKGKST STSKTKFDTS IVDFIEKPKT EISEVLPEEK 660
RKAICDESQT VRVSIDRGVT KTRDVSSPVS DEKSENVNHE EANSGHTVMN VHSSLDPQPI 720
VQPNELESGS YLKDLPDRNV GNSEKVTFQE DDINSPKLQS KNNQTVEAVN TETSDKLQEK 780
EANHELENIE KIEEKLTEVD KVSLSDAFPD QEIKNSRTSV QNGTRSVSKN TPEKETKVDK 840
IDNVSKKDVE TSPGSCETSS AFAKTYAEKE VTSINLPSVR KPLDESYYDH SISPFDPLCQ 900
SSFLAPQTPV KSKHALPLVE ANAPPWEPID FSSLLESPVP NPVEPNKLSE KELDMTVEQW 960
IKFMYAKCAK EFEEACEEKI EWLLEEGKRA EEYIQNL
998Fasta Sequence
>O14064|bir1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MKPITSSSKRRWNRFRREMCNYSKRLDTFQKKKWPRAKPTPETLATVGFYYNPISESNSEERLDNVTCYMCTKSFYDWEDDDDPLKEHITHSPSCPWAYILSSKNNPNQNPQAAALTKCREQTFVDKVWPYTNRPDYHCEPSVMAASGFVYNPTADAKDAAHCLYCDINLHDWEPDDDPYTEHKRRRADCVFFTWKDPNSLSPTKLSFLSTSNIDPEDLTEDNSILPVSPTRDSTKSHKTLNFSPSRKNNLNARPLTMSLYTNTSEEKDSQPTRAPQSPTKPVLLTAPRRKNKSPKKSKPAVFKPVKPIFSDEDEDDDDLTASQPFSKGICNDSMQVAKKNFTEEIPLKEDEKDNELEHLVSPATSVHTTVSDITGHQSVTDESDEQNNCMSTPPKIEIESKIEEEISVVSKSKEISSSVSSVGKEQNHTEKQVAIETPEQQKVEKEDEHLNLQGSFIEESTKQPISSKPSTSSPDMTDAATGGRVSSSSFRDKILQTNFSPRSTIDSFSNISKKRNSEEANDENDETNLKIPIPEKKRKFQEVLQSKNILVSSTEDSHEPVKVTEDSQTAIHVSKFEDLENKSMESEQSLQLLSESENDDKPLIDLIPLLAIKRKDNLVSGVLEKGKSTSTSKTKFDTSIVDFIEKPKTEISEVLPEEKRKAICDESQTVRVSIDRGVTKTRDVSSPVSDEKSENVNHEEANSGHTVMNVHSSLDPQPIVQPNELESGSYLKDLPDRNVGNSEKVTFQEDDINSPKLQSKNNQTVEAVNTETSDKLQEKEANHELENIEKIEEKLTEVDKVSLSDAFPDQEIKNSRTSVQNGTRSVSKNTPEKETKVDKIDNVSKKDVETSPGSCETSSAFAKTYAEKEVTSINLPSVRKPLDESYYDHSISPFDPLCQSSFLAPQTPVKSKHALPLVEANAPPWEPIDFSSLLESPVPNPVEPNKLSEKELDMTVEQWIKFMYAKCAKEFEEACEEKIEWLLEEGKRAEEYIQNL
|
| Keyword |
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
|
| Interpro |
IPR001370--BIR_rpt
|
| PROSITE |
PS50143--BIR_REPEAT_2
|
| Pfam |
PF00653--BIR
|
| Gene Ontology |
GO:0032133--C:chromosome passenger complex
GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0005737--C:cytoplasm
GO:1990023--C:mitotic spindle midzone
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007076--P:mitotic chromosome condensation
GO:0000281--P:mitotic cytokinesis
GO:0000070--P:mitotic sister chromatid segregation
GO:0090307--P:mitotic spindle assembly
GO:0034501--P:protein localization to kinetochore
GO:0034503--P:protein localization to nucleolar rDNA repeats
GO:0016567--P:protein ubiquitination
GO:0009966--P:regulation of signal transduction
|
