dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000552
Uniprot Accession O14027; PDX1_SCHPO;
Genbank Protein ID NP_594982.1;
Genbank Nucleotide ID NM_001020413.2;
Protein Name Probable pyridoxal 5'-phosphate synthase subunit PDX1
Protein Synonyms/Alias
Gene Name snz1
Gene Synonyms/Alias SPAC29B12.04;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
178GELRRVKSMSPDELYdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
180LRRVKSMSPDELYTYdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
283AMVGRSVSSLEEKEKdbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)		MSAEIKGSTQ VKAGLAQMLK GGVIMDVVNA EQARIAEAAG ACAVMALERV PADIRAQGGV 60
ARMSDPSMIK EIQAAVSIPV MAKVRIGHFV EAQILESIGV DYIDESEVLT PADDINHIEK 120
SKFTVPFVCG SRNLGEALRR ISEGAAMIRT KGEAGTGDVV EAVRHTRQMQ GELRRVKSMS 180
PDELYTYAKE IAAPIDLVKE CAQLGRLPVV NFAAGGVATP ADAALMMQLG CDGVFVGSGI 240
FLSGDPAKRA RAIVRAVTHY NDPKILAEVS ENLGAAMVGR SVSSLEEKEK LATRGW 297
Keyword

KW-0181--Complete proteome
KW-0456--Lyase
KW-0597--Phosphoprotein
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0704--Schiff base
Interpro

IPR013785--Aldolase_TIM
IPR001852--PdxS/SNZ
IPR011060--RibuloseP-bd_barrel
PROSITE

PS01235--PDXS_SNZ_1
PS51129--PDXS_SNZ_2
Pfam

PF01680--SOR_SNZ
Gene Ontology

GO:0005829--C:cytosol
GO:0036381--F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
GO:0042823--P:pyridoxal phosphate biosynthetic process
GO:0008615--P:pyridoxine biosynthetic process