dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000551
Uniprot Accession O14026; SET2_SCHPO;
Genbank Protein ID NP_594980.1;
Genbank Nucleotide ID NM_001020411.2;
Protein Name Histone-lysine N-methyltransferase, H3 lysine-36 specific
Protein Synonyms/Alias Lysine N-methyltransferase 3;SET domain-containing protein 2;
Gene Name set2
Gene Synonyms/Alias kmt3;SPAC29B12.02c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
67SAPSPSTSSPSSASSdbPTM 3.0;UniProt18257517; 16381945; 23193290
545KSAINNSTEDLSKKHdbPTM 3.0;UniProt18257517; 16381945; 23193290
561ALHSSRPSDSRSRSKcurated22817900
563HSSRPSDSRSRSKFGcurated22817900
594FPKRRRLSNSDTPSEdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
596KRRRLSNSDTPSETTdbPTM 3.0;UniProt18257517; 16381945; 23193290
783RSGTATTTPTDSPSIdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
785GTATTTPTDSPSIGEdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
787ATTTPTDSPSIGESPdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
789TTPTDSPSIGESPKKdbPTM 3.0;UniProt18257517; 16381945; 23193290
793DSPSIGESPKKAA--dbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)		MQTASSLSVL TPLNEENVDR KSSWSKDTIA VQAVGSSPSS SSSHDFESKE DAEGMNKDES 60
APSPSTSSPS SASSRSQSKY VRKEALPPQL FHHLDSAKDK ALTTFEEIQE CQYASANIGK 120
PPENEAMICD CRPHWVDGVN VACGHGSNCI NRMTSIECTD EDNVCGPSCQ NQRFQRHEFA 180
KVDVFLTEKK GFGLRADANL PKDTFVYEYI GEVIPEQKFR KRMRQYDSEG IKHFYFMMLQ 240
KGEYIDATKR GSLARFCNHS CRPNCYVDKW MVGDKLRMGI FCKRDIIRGE ELTFDYNVDR 300
YGAQAQPCYC GEPCCVGYIG GKTQTEAQSK LPENVREALG IEDEEDSWEN ITARRQRRKK 360
GIDETSKIIE EVQPTPLTSE SATKVIGVLL QTKDDLLTRK LMERIFLTSD PSVCRSIIAL 420
RGYNIFGLML KKFSIDIEFI LRSIKTMLSW PRLTRNKIQD SNIEPVVQEF CDHENEEVKD 480
HAKTLLKEWE SLEIAYRIPR RKPGQVAPQS TNAEPSNNQS NPPLRDQEPQ RGDKGDIKSA 540
INNSTEDLSK KHPALHSSRP SDSRSRSKFG NDYQSHSKHN LFRKNSFPKR RRLSNSDTPS 600
ETTTPNNEQE QVSNQANKVD LNKIISAAME SVNQKNVLKA QKEEEERIAQ QKREEKRRLA 660
YEESLKRHAK KLHEKKTKSS QDATIDHHLT SHSPESIAFK AVLAKFFANK TARYQEKLGK 720
AEFKLRVKKM TEIILKKHIQ LVLSKKEKAL PDELSDSQQR KLRVWAFRYL DTVVSRSGTA 780
TTTPTDSPSI GESPKKAA 799
Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
Interpro

IPR006560--AWS_dom
IPR025788--Hist-Lys_N-MeTrfase_SET2_fun
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR013257--SRI
IPR017923--TFIIS_N
PROSITE

PS51215--AWS
PS50868--POST_SET
PS51568--SAM_MT43_SET2_1
PS50280--SET
Pfam

PF00856--SET
PF08236--SRI
Gene Ontology

GO:0016591--C:DNA-directed RNA polymerase II, holoenzyme
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0010452--P:histone H3-K36 methylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter