dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000548
Uniprot Accession O13995; DAP1_SCHPO;
Genbank Protein ID NP_594461.1;
Genbank Nucleotide ID NM_001019890.2;
Protein Name Cytochrome P450 regulator dap1
Protein Synonyms/Alias
Gene Name dap1
Gene Synonyms/Alias SPAC25B8.01;SPAC26H5.15;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Required for sterol biosynthesis. Functions as a positive regulator of cytochrome P450 enzymes erg5 and erg11. Function requires bound heme.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
108DDEFIPDSDAEELDDdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MASTQVVFIV TLFLYLLITR WRRKNEKSFI ASEEPKQPEW RDYTPAELKE YNGSKNSLVF 60
LAIKGTVYNV TMGSKFYGPQ GPYSAFAGHD ASRGLAKNSF DDEFIPDSDA EELDDCSDLN 120
DEERQALNDW KAFFDQKYQA VGRLISPREA RAAATISETE EKVAHN 167
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0349--Heme
KW-0408--Iron
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0346--Stress response
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001199--Cyt_B5-like_heme/steroid-bd
PROSITE
Pfam

PF00173--Cyt-b5
Gene Ontology

GO:0012505--C:endomembrane system
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0008047--F:enzyme activator activity
GO:0020037--F:heme binding
GO:0046872--F:metal ion binding
GO:0005496--F:steroid binding
GO:0006696--P:ergosterol biosynthetic process
GO:0043085--P:positive regulation of catalytic activity
GO:0032443--P:regulation of ergosterol biosynthetic process