dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000547
Uniprot Accession O13994; KEI1_SCHPO;
Genbank Protein ID NP_594460.1;
Genbank Nucleotide ID NM_001019889.2;
Protein Name Inositol phoshorylceramide synthase regulatory subunit kei1
Protein Synonyms/Alias
Gene Name kei1
Gene Synonyms/Alias SPAC26H5.13c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
224HTKRFTDSIELEQRLcurated22817900
Sequence
(Fasta)
MALFRRPNWS ALFEKIFIQK SFLGFCSLRV GCEIIIWFAI INKVSGLYGI VSLFQNSDAS 60
PWQVLMYVSS VLMLILFSWL AIHIPKSSVP HALILFYVYL IDFLLNVLFT VLFALSWFSK 120
LVQSDSSSTE ESADSDPSPS LLYLFFQAES IPSLLLLIFF ASLKFYFVLI TLSYSNKLIV 180
DSGIRPQNLP PNFSGRVTRL LMKPYIMAAN RSYLRNHTKR FTDSIELEQR LMDEVV 237
Keyword

KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-1185--Reference proteome
KW-0746--Sphingolipid metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR013862--DUF1753_Golgi

PROSITE
Pfam

PF08552--Kei1

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0070916--C:inositol phosphoceramide synthase complex
GO:0030173--C:integral component of Golgi membrane
GO:0070917--F:inositol phosphoceramide synthase regulator activity
GO:0006673--P:inositolphosphoceramide metabolic process
GO:0050790--P:regulation of catalytic activity
GO:0030148--P:sphingolipid biosynthetic process