dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000541
Uniprot Accession O13953; EAF3_SCHPO;
Genbank Protein ID NP_593394.1;
Genbank Nucleotide ID NM_001018826.2;
Protein Name Chromatin modification-related protein eaf3
Protein Synonyms/Alias Altered polarity protein 13;ESA1-associated factor 3;
Gene Name alp13
Gene Synonyms/Alias eaf3;SPAC23H4.12;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Also involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
105VKTSGKRSRESSTVTcurated22817900
131IKTQKSESPIPQQVKdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MAVSYKVNER VLCFHGPLLY EAKIVDTEMK GDVTTYLIHY KGWKNSWDEW VEQDRILQWT 60
EENLKTQKEL KNAAISTRQK PTSKKSASST SKHDSTGVKT SGKRSRESST VTVDGDSHEL 120
PSRIKTQKSE SPIPQQVKRD GTTDAKNEET TKPENNEKDD FEEEPPLPKH KISVPDVLKL 180
WLVDDWENIT KNQQLIAIPR NPTVRAAIAA FRESKISHLN NEIDVDVFEQ AMAGLVIYFN 240
KCLGNMLLYR FERQQYLEIR QQYPDTEMCD LYGVEHLIRL FVSLPELIDR TNMDSQSIEC 300
LLNYIEEFLK YLVLHKDEYF IKEYQNAPPN YRSLVGV 338
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot
PROSITE

PS51640--MRG
Pfam

PF05712--MRG
PF11717--Tudor-knot
Gene Ontology

GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0032221--C:Rpd3S complex
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006338--P:chromatin remodeling
GO:0006281--P:DNA repair
GO:0071963--P:establishment or maintenance of cell polarity regulating cell shape
GO:0016573--P:histone acetylation
GO:0016575--P:histone deacetylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated