dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000537 |
| Uniprot Accession | O13936; SPT5_SCHPO; Q9US64; |
| Genbank Protein ID | NP_593191.1; |
| Genbank Nucleotide ID | NM_001018587.2; |
| Protein Name | Transcription elongation factor spt5 |
| Protein Synonyms/Alias | Chromatin elongation factor spt5; |
| Gene Name | spt5 |
| Gene Synonyms/Alias | SPAC23C4.19; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MDTNSPKSID KDANSTEVDA AEQDAASVKI NSTRASPNGS DLLNDDSEAA KITTNEKQSS 60 PVDSHNESPN DTTINKGEDG NENEVDNVNN NDKKEDEDNV EENEEEADAN EEEEEDEEDD 120 EEDEEDEDES GGGRRKRARH DRRNQFLDIE AEVDEDEEEL EDEEDEIGRE DGFIEEEVGA 180 DYVGDDRRHR ELDRQRQELQ SVDAERLAEE YREKYGRSQT VVGDTSNVPQ RLLLPSVNDP 240 NIWAVRCKIG KEKDIVFTIM RKAMDLQYTS SPLEIISAFQ RDSLVGYIYV EARKQSHVLD 300 ALNGVLNVYT NNMILVPIKE MPDLLKVQKQ VVELLPGAYV RIRRGKYAGD LAQVDNLSEN 360 GLTARVRIVP RIDYSDGLKR KNSATRPQAR LFNESEAFKS NPSKFSKRGP RLFLFNNEEF 420 EDGFLVKDIR ISSLITEGVN PTLDEVSKFN PNNEDLDLSS LALSVKGGHA EFQPGDHVEV 480 YVGEQTGVSG VVENVRGSVI TMVSSDGLRL DVPSRGLRKR FRHGDYVKVI AGKYKDDTGM 540 VVRISKDEVT FLSDTLMTEL TVFSRDLGEA SSAQAVNSAY ELHDLVQLDV NTVACIFSVD 600 RDTYKVIDQN GGVRTVLASQ ITMRHSNRRG VATDRNGAEI RIGDKVKEVG GEGKQGTILH 660 IYRAFVFLHN RDIAENNGVF SARSRNVATI AAKGARISAD LTKMNPALSN GPALPPVANL 720 KRTIGRDKAI GATVRIRRGP MKGLLGVIKD TTDANARVEL HTGNKMVTIP KENLLYTTKT 780 GELISYTEFI ERSRGIRPGS ISTADGPNVP NWAQGARTPA VANGSRTPAW NTGSRTPAWN 840 SGSKTPAWNS GSRTPAWNSG NKTPAWNAGS RTPAWNSGNK TPAWNVGNKT PAWNSGAKTP 900 AWNAGNKTPS WNNGTKTPAW NANQTPMVAN GTNTSWGQTP AYGGFSETNW DTEDNSKPYT 960 APTPGAWAAP TPGGWDDEEG DSPKYVPPSP 991 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR005824--KOW |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0032044--C:DSIF complex |