dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000534
Uniprot Accession O13919; PST2_SCHPO;
Genbank Protein ID NP_593646.1;
Genbank Nucleotide ID NM_001019077.2;
Protein Name Paired amphipathic helix protein pst2
Protein Synonyms/Alias SIN3 homolog 2;
Gene Name pst2
Gene Synonyms/Alias SPAC23C11.15;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
641KPVRRKRSNSITQLTdbPTM 3.0;UniProt18257517; 16381945; 23193290
643VRRKRSNSITQLTEFdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
881VEQNSSASPKKNYDDdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MEQTLAILKN DNSTLVAEMQ NQLVHDFSPN GTALPELDIK AFVQKLGQRL CHRPYVYSAF 60
MDVVKALHNE IVDFPGFIER ISVILRDYPD LLEYLNIFLP SSYKYLLSNS GANFTLQFTT 120
PSGPVSTPST YVATYNDLPC TYHRAIGFVS RVRRALLSNP EQFFKLQDSL RKFKNSECSL 180
SELQTIVTSL LAEHPSLAHE FHNFLPSSIF FGSKPPLGSF PLRGIQSSQF TLSNISDLLS 240
QSRPDNLSPF SHLSNESSDF FKNVKNVLTD VETYHEFLKL LNLYVQGIID RNILVSRGFG 300
FLKSNSGLWR SFLSLTSLSP EEFLSVYNSA CSDFPECGPS YRLLPVEERN ISCSGRDDFA 360
WGILNDDWVS HPTWASEESG FIVQRKTPYE EAMTKLEEER YEFDRHIEAT SWTIKSLKKI 420
QNRINELPEE ERETYTLEEG LGLPSKSIYK KTIKLVYTSE HAEEMFKALE RMPCLTLPLV 480
ISRLEEKNEE WKSVKRSLQP GWRSIEFKNY DKSLDSQCVY FKARDKKNVS SKFLLAEADI 540
LRSQAKLHFP LRSRSAFEFS FVYDNEIVLF DTCYMVCTYI VCNSPSGLKK VEHFFKNILP 600
LHFGLEKDKF SIFLDQVFRG PDYDVNAPNI VGNKPVRRKR SNSITQLTEF VKQPKINGQR 660
ESRSAAAARK KEESGNKSQS NSQNSLSDES GNVTPVSKKQ LSQPAAAIKA SLKYPSHPDS 720
LLEHQDHAGD TENEMHDDVD KEQFGYSSMY VFFRLFNLLY ERLYELQRLE DQVSIIQQRI 780
IPNPVSQKQK IWRDRWNDLS DVPDEKTHYE NTYVMILRLI YGIVDQSAFE DYLRFYYGNK 840
AYKIYTIDKL VWSAAKQVHH IVSDGKYKFV TSLVEQNSSA SPKKNYDDFL YRLEIEKLLN 900
PDEILFRFCW INKFKSFGIK IMKRANLIVD QSLDTQRRVW KKYVQNYRIQ KLTEEISYKN 960
YRCPFLCRNI EKERTVEQLV SRLQTKLLRS AELVSGLQAK LCLDSFKLLY LPRTEDSYID 1020
ASYLRLRDTD FLDCQNKRKQ RWRNRWESLL KSVRGTSDNT AEVNFDADIN ALFIP 1076
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR013194--HDAC_interact
IPR003822--PAH
IPR031693--Sin3_C
PROSITE

PS51477--PAH
Pfam

PF08295--Sin3_corepress
PF16879--Sin3a_C
Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0032221--C:Rpd3S complex
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0003714--F:transcription corepressor activity
GO:0006338--P:chromatin remodeling
GO:0006342--P:chromatin silencing
GO:0016575--P:histone deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated