| Tag |
Content |
| dbPAF ID |
dbPAF-0000532 |
| Uniprot Accession |
O13911; PNK1_SCHPO;
|
| Genbank Protein ID |
NP_593635.2;
|
| Genbank Nucleotide ID |
NM_001019066.2;
|
| Protein Name |
Bifunctional polynucleotide phosphatase/kinase |
| Protein Synonyms/Alias |
DNA 5'-kinase/3'-phosphatase;Polynucleotide kinase-3'-phosphatase; |
| Gene Name |
pnk1 |
| Gene Synonyms/Alias |
SPAC23C11.04c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA.Functional Description
Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MSSKKRKSPP QESLTSYFEK SSKSSKKYGS QNKDSDSSST CLQQKIEIQW SITDSLYIAK 60
YGKLKKTKKF IAFDLDGTLI KTKSGRVFSK DAADWTWWHP SVVPKLKALY QDNYSLVIFS 120
NQNGIPRKPS AGHTFQMKIR AIFESLDLPI VLYAAILKDK FRKPLTGMWN SFLKDVNRSI 180
DLSFIKYVGD AAGRPGDHNS TDLKFAENIG IKFETPEQFF LGHSFVPPNF ESFHPKNYLV 240
RNSSSHPYHF KKSEHQEIVV LVGFPSSGKS TLAESQIVTQ GYERVNQDIL KTKSKCIKAA 300
IEALKKEKSV VIDNTNPTIE SRKMWIDIAQ EFEIPIRCIH LQSSEELARH NNVFRYIHHN 360
QKQLPEIAFN SFKSRFQMPT VEEGFTNVEE VPFKCLKDYE DTWNYWYE
409Fasta Sequence
>O13911|pnk1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MSSKKRKSPPQESLTSYFEKSSKSSKKYGSQNKDSDSSSTCLQQKIEIQWSITDSLYIAKYGKLKKTKKFIAFDLDGTLIKTKSGRVFSKDAADWTWWHPSVVPKLKALYQDNYSLVIFSNQNGIPRKPSAGHTFQMKIRAIFESLDLPIVLYAAILKDKFRKPLTGMWNSFLKDVNRSIDLSFIKYVGDAAGRPGDHNSTDLKFAENIGIKFETPEQFFLGHSFVPPNFESFHPKNYLVRNSSSHPYHFKKSEHQEIVVLVGFPSSGKSTLAESQIVTQGYERVNQDILKTKSKCIKAAIEALKKEKSVVIDNTNPTIESRKMWIDIAQEFEIPIRCIHLQSSEELARHNNVFRYIHHNQKQLPEIAFNSFKSRFQMPTVEEGFTNVEEVPFKCLKDYEDTWNYWYE
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0418--Kinase
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR023214--HAD-like_dom
IPR006549--HAD-SF_hydro_IIIA
IPR027417--P-loop_NTPase
IPR013954--PNK3P
IPR006551--Polynucleotide_phosphatase
|
| PROSITE |
|
| Pfam |
PF08645--PNK3P
|
| Gene Ontology |
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046404--F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0003690--F:double-stranded DNA binding
GO:0019201--F:nucleotide kinase activity
GO:0046403--F:polynucleotide 3'-phosphatase activity
GO:0006284--P:base-excision repair
GO:0098504--P:DNA 3' dephosphorylation involved in DNA repair
GO:0046939--P:nucleotide phosphorylation
GO:0098506--P:polynucleotide 3' dephosphorylation
GO:0000012--P:single strand break repair
|
