dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000514
Uniprot Accession O13838; NUP40_SCHPO;
Genbank Protein ID NP_593304.1;
Genbank Nucleotide ID NM_001018734.2;
Protein Name Nucleoporin nup40
Protein Synonyms/Alias Nuclear pore protein nup40;
Gene Name nup40
Gene Synonyms/Alias SPAC19E9.01c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
88SFRLSLSSPPSSKFGdbPTM 3.0;UniProt18257517; 16381945; 23193290
92SLSSPPSSKFGGPSFdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MSFGGSGSIT NRSTLKPLSV DDLRSPSPQK EYRGFRTSVS NIPQEKKFVP SHLSHFGSSQ 60
QRRFAPEVSS PLAEPYESSS SFRLSLSSPP SSKFGGPSFG TPKPFLHTNR LGTGSLIEDA 120
PPTQSIYDFS SSRQINALNV GQSSSPFSPV SEKVYDPSFT MSGAPQDSNT SVIVFGFPPE 180
LTNQVIAEFS RFGTIISENS LTASSAGFTP SKGPISGNWL QLTYAEPSSA AKAVLSNGML 240
INDSFMVGCI YSPAEAKEHV PKTLRNSNKD LEMTDASSSE TSMSIPVHAD AHFQSQSGLG 300
KKVIVQHKND IFKSSQKHQP RNWLFHYLFG FGSTEPIDEE EKSKTASDNT SLQTSLFGKI 360
VQVVLHTLFG F 372
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR007846--RRM_NUP35_dom

PROSITE

PS51472--RRM_NUP35

Pfam

PF05172--Nup35_RRM

Gene Ontology

GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0034399--C:nuclear periphery
GO:0005643--C:nuclear pore
GO:0051028--P:mRNA transport
GO:0015031--P:protein transport
GO:0006407--P:rRNA export from nucleus