dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000508 | ||||||||
| Uniprot Accession | O13824; NMD2_SCHPO; | ||||||||
| Genbank Protein ID | NP_593784.1; | ||||||||
| Genbank Nucleotide ID | NM_001019213.2; | ||||||||
| Protein Name | Nonsense-mediated mRNA decay protein 2 | ||||||||
| Protein Synonyms/Alias | Up-frameshift suppressor 2; | ||||||||
| Gene Name | upf2 | ||||||||
| Gene Synonyms/Alias | SPAC19A8.08; | ||||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) | ||||||||
| NCBI Taxa ID | 284812 | ||||||||
| Functional Description (View all) |
Involved in nonsense-mediated decay of mRNAs containing premature stop codons. It interacts, via its C-terminus, with NAM7/UPF1. Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSREEQIKKL NQYLDNRELA FRAKDGDKNI FHTESQLDSS LKKNTAFMKR CKSSLTSENY 60 DSFIKEIKTL SLKKFIPEIT AAIVEGMMKC KATKDILSSV KIVWALNLRF STAFTGPMLA 120 NLYCALYPNP GYSLCHESYF ELKQNENEVS EKDRSSHLLK VRPLLRFLIE FWLNGVVGTP 180 EDFVSYLPST DSNDKKFRKP WFEEQNLKKP LVVLLFNDLM DTRFGFLLLP VLTSLVRTFS 240 CELFTTEDFE DKETLELVNR LNPVVWRTYL RKSLNSYVDK LEVYCQKRKS LFEELNKQYQ 300 EQSIIRADPN NEKFQRLANF SKSIESEFSS YASLSEVLNR KASEDLLELN FMEKASSGTN 360 SVFNASGERS ESANVETAQV WDDREQYFFY EVFPNFNEGS IAEMKSSIYE SSQEGIRSSS 420 ENNKKEDDLK DSTGDLNTTQ VSSRVDNFLL KLPSMVSLEL TNEMALEFYD LNTKASRNRL 480 IKALCTIPRT SSFLVPYYVR LARILSQLSS EFSTSLVDHA RHSFKRMIHR KAKHEYDTRL 540 LIVRYISELT KFQLMPFHMV FECYKLCINE FTPFDLEVLA LLLESCGRFL LRYPETKLQM 600 QSFLEAIQKK KLASALASQD QLVLENALHF VNPPKRGIIV SKKKSLKEEF LYDLIQIRLK 660 DDNVFPTLLL LRKFDWKDDY QILYNTIMEV WNIKYNSLNA LARLLSALYK FHPEFCIHVI 720 DDTLESLFSA VNNSDHVEKQ KRLAQARFIS ELCVIHMLDV RAITNFLFHL LPLEKFESFL 780 TMKASTLTNI NNDMFRLRLI VVVLQTCGPS IIRSKTKKTM LTYLLAYQCY FLIQPEMPLD 840 MLYEFEDVIG YVRPSMKVYM HYEEARNALT ERLQAISDDW EEDDTRPVFQ GANDGDISSN 900 EESVYLPEDI SDESETDEES SGLEESDLLD SEDEDIDNEM QLSRELDEEF ERLTNESLLT 960 RMHEKNPGFD VPLPLRASSL GSPYVTRNEE SASESSHVMF TLLTKRGNKQ RSQYLEIPSH 1020 SSLVRSTKNQ QTEEIMERKR VKEMVLNFE |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR016024--ARM-type_fold |
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| PROSITE | |||||||||
| Pfam | |||||||||
| Gene Ontology | GO:0005737--C:cytoplasm |