| Tag |
Content |
| dbPAF ID |
dbPAF-0000500 |
| Uniprot Accession |
O13792; SUB2_SCHPO; P78919;
|
| Genbank Protein ID |
NP_594261.1;
|
| Genbank Nucleotide ID |
NM_001019684.2;
|
| Protein Name |
ATP-dependent RNA helicase uap56 |
| Protein Synonyms/Alias |
|
| Gene Name |
uap56 |
| Gene Synonyms/Alias |
sub2;SPAC17G6.14c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).Functional Description
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC). |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MASAQEDLID YEEEEELVQD QPAQEITPAA DTAENGEKSD KKGSYVGIHS TGFRDFLLKP 60
ELLRAITDSG FEHPSEVQQV CIPQSILGTD VLCQAKSGMG KTAVFVLSTL QQIEPVDGEV 120
SVLVLCHTRE LAFQIKNEYA RFSKYLPDVR TAVFYGGINI KQDMEAFKDK SKSPHIVVAT 180
PGRLNALVRE KILKVNSVKH FVLDECDKLL ESVDMRRDIQ EVFRATPPQK QVMMFSATLS 240
NEIRPICKKF MQNPLEIYVD DETKLTLHGL QQHYVKLEEK AKNRKINDLL DSLEFNQVVI 300
FVKSVSRANE LDRLLRECNF PSICIHGGLP QEERIKRYKA FKDFDKRICV ATDVFGRGID 360
IERVNIVINY DMPDSPDSYL HRVGRAGRFG TKGLAITFSS SEEDSQILDK IQERFEVNIT 420
ELPDEIDVGS YMNA
435Fasta Sequence
>O13792|uap56|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MASAQEDLIDYEEEEELVQDQPAQEITPAADTAENGEKSDKKGSYVGIHSTGFRDFLLKPELLRAITDSGFEHPSEVQQVCIPQSILGTDVLCQAKSGMGKTAVFVLSTLQQIEPVDGEVSVLVLCHTRELAFQIKNEYARFSKYLPDVRTAVFYGGINIKQDMEAFKDKSKSPHIVVATPGRLNALVREKILKVNSVKHFVLDECDKLLESVDMRRDIQEVFRATPPQKQVMMFSATLSNEIRPICKKFMQNPLEIYVDDETKLTLHGLQQHYVKLEEKAKNRKINDLLDSLEFNQVVIFVKSVSRANELDRLLRECNFPSICIHGGLPQEERIKRYKAFKDFDKRICVATDVFGRGIDIERVNIVINYDMPDSPDSYLHRVGRAGRFGTKGLAITFSSSEEDSQILDKIQERFEVNITELPDEIDVGSYMNA
|
| Keyword |
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0509--mRNA transport
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0747--Spliceosome
KW-0813--Transport
|
| Interpro |
IPR011545--DEAD/DEAH_box_helicase_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR014014--RNA_helicase_DEAD_Q_motif
|
| PROSITE |
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51195--Q_MOTIF
|
| Pfam |
PF00270--DEAD
PF00271--Helicase_C
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0000346--C:transcription export complex
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0003723--F:RNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031124--P:mRNA 3'-end processing
GO:0006406--P:mRNA export from nucleus
GO:0000398--P:mRNA splicing, via spliceosome
GO:0010468--P:regulation of gene expression
GO:0010501--P:RNA secondary structure unwinding
|
