dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000498
Uniprot Accession O13788; SSR1_SCHPO;
Genbank Protein ID NP_594257.1;
Genbank Nucleotide ID NM_001019680.2;
Protein Name SWI/SNF and RSC complexes subunit ssr1
Protein Synonyms/Alias
Gene Name ssr1
Gene Synonyms/Alias SPAC17G6.10;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
271YQQNRFPSPTTIADYcurated22817900
422LEDSDSLSELYLTNEcurated22817900
Sequence
(Fasta)		MSNVTENKHD LHENGVPDSA QPMELDVSKK EDTEPEVRDE AKEFLLSQLP QVEVPEWAQW 60
FDFSKVHEIE KKQNPEFFDG KNTSKTPEVY KEYRDFMIST FRLNSKVYLT FTACRRNLAG 120
DVCAVLRVHR FLEQWGLINY NVNPDTRPSK IGPPSTSHFQ ILADTPRGLV PLLPPPSSSI 180
PRSKAVTIED PSIVRTNIYD PSLDDVLKGK GSTPNQKPSL SNLHENNIDQ SDSPQHCYCC 240
GNKFNESYYQ SQTAQKYNVC ISCYQQNRFP SPTTIADYKE VAIQNKIEDD DTWTAQELVL 300
LSEGVEMYSD DWAKVASHVN TKSVEECILK FLNLPSSDKA LFKMDKVHTN PVVDSLQGKN 360
PILSVVSFLA KMVPPSSFTQ KSSAKEEESD KVKGESVYPK PESESYDVEM NGKSLEDSDS 420
LSELYLTNEE KKMASIIKDS VNVQIKLIES KLSHFDYLDQ HIRLKSQELD AFAQATYREK 480
LYMKRECQNA RKKIEQQLQS KDTAANGLPV QSSAETSVIP ASSMSPS 528
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR009057--Homeodomain-like
IPR001005--SANT/Myb
IPR017884--SANT_dom
IPR032451--SMARCC_C
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS51293--SANT
PS50934--SWIRM
Pfam

PF00249--Myb_DNA-binding
PF04433--SWIRM
PF16495--SWIRM-assoc_1
Gene Ontology

GO:0005829--C:cytosol
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0016586--C:RSC complex
GO:0016514--C:SWI/SNF complex
GO:0003677--F:DNA binding
GO:0006338--P:chromatin remodeling
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated