dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000493
Uniprot Accession O13774; GCH1_SCHPO;
Genbank Protein ID NP_593481.1;
Genbank Nucleotide ID NM_001018914.1;
Protein Name GTP cyclohydrolase 1
Protein Synonyms/Alias GTP cyclohydrolase I;GTP-CH-I;
Gene Name SPAC17A5.13
Gene Synonyms/Alias
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
11GKKDYIDSPLRMQPAcurated22817900
25ASLSGASTPTIDLDGdbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)		MEPGKKDYID SPLRMQPASL SGASTPTIDL DGLSWPCQGT QRRIDTAEEE KVKKISNAIS 60
TILECLGEDP ERQGLLGTPE RYAKAMLYFT KGYEQNLTEV INEAVFQEDH EEMVIVRDID 120
VFSLCEHHLV PFIGKIHIGY IPRKRVLGLS KLARIANMFS RRLQVQERLT KQVAQAIQAV 180
LKPQGVAVVM EATHMCMVMR GVEKPGSSTV TSSLTGIFQR SHKTREEFFR LIGKF 236
Keyword

KW-0021--Allosteric enzyme
KW-0181--Complete proteome
KW-0289--Folate biosynthesis
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR001474--GTP_CycHdrlase_I
IPR018234--GTP_CycHdrlase_I_CS
IPR020602--GTP_CycHdrlase_I_dom
PROSITE

PS00859--GTP_CYCLOHYDROL_1_1
PS00860--GTP_CYCLOHYDROL_1_2
Pfam

PF01227--GTP_cyclohydroI
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0008270--F:zinc ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0046656--P:folic acid biosynthetic process
GO:0009396--P:folic acid-containing compound biosynthetic process
GO:0006729--P:tetrahydrobiopterin biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process