dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000485
Uniprot Accession O13736; SLA1_SCHPO;
Genbank Protein ID NP_594213.1;
Genbank Nucleotide ID NM_001019636.2;
Protein Name Actin cytoskeleton-regulatory complex protein sla1
Protein Synonyms/Alias
Gene Name sla1
Gene Synonyms/Alias SPAC16E8.01;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
220YSSGRAVSPEIPPTYcurated22817900
226VSPEIPPTYTPKQADcurated22817900
309HSYDSPPSPSSPSDAdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
311YDSPPSPSSPSDAYGdbPTM 3.0;UniProt18257517; 16381945; 23193290
312DSPPSPSSPSDAYGDdbPTM 3.0;UniProt18257517; 16381945; 23193290
454EIAAASGSPMPKLPSdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
461SPMPKLPSDSALHRLcurated22817900
573DTEGDAKSPPSSSKSdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
577DAKSPPSSSKSGQGSdbPTM 3.0;UniProt18257517; 16381945; 23193290
919EVVEKAPSPPATRPKcurated22817900
927PPATRPKSTTPQKFDdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
928PATRPKSTTPQKFDDcurated22817900
929ATRPKSTTPQKFDDDdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
952EPPVRASSVTVEPARcurated22817900
984EAPSRPRTAPIPEPEcurated22817900
Sequence
(Fasta)		MANLPIIGIY KVLYSYEPQE INPGEEIPEN EREISIVEDE IVCLLEKGED DWYLVKRNVN 60
SNDDDEEIGI VPSNYITEAE PSTKMKALYD YTQQSVDEIS FQADQTLDCY GDTDSDWILV 120
GFNNNFGLAP RNYVEGMDAS SAPASQEPSA SGVNAPTVSA PNSMVSPPPS FQPPSAAAPA 180
TSLPSDYNPP PPPPPPPAVE DQAADANEPD DYYSSGRAVS PEIPPTYTPK QADPLPAPPP 240
PPPPTLPPQS TNTSQLPMPS RNVNNLGSQV NIPPPPATPS QPPRPPTNAS TRSTGTSSSM 300
AHSYDSPPSP SSPSDAYGDP NQHLKLRTDS HDDSRAYDSS SSMGNPAYEK WEVREVVGKK 360
KKRTGILAIN NKSIVLTFTK TMDAAQVWPV TDLVNYSSER KHVFIEFNSD SGITSLHLHA 420
SSNTNADNII RALGDVAGSA RAAGLREIAA ASGSPMPKLP SDSALHRLNA ASDAAGVNGG 480
RTGDYEMSTV YGDRSARAED HKPKDSSAGQ KMGTVLYDFI AEAADELTVK ANMRVVIVND 540
TASSDWWKCS VDGKEGVVPS NFIKPDTEGD AKSPPSSSKS GQGSSLSRRA SKHESKHKRD 600
SKHEARPESK HESHRESKSA EKDKKDKKDK KEDSKRSRSH SVSKPDSSKL RTWTDRTGAF 660
KVEAEFLGYS DDKIHLHKTN GVKISVPSAK MSYKDLDYVE LMTGKKVYSR TERKKDTQKQ 720
SHDHGHSHSK SHDREKEKEK KKDREHRKHR ETEEEDEGPP PQPARPESTR PALAPPSSSH 780
SNDKYDVIQE RPKISYDWFD FFLRCGVDFT VCNRYTHNFN NEHLDEACIP SLNPDTLRTL 840
GLKEGDIIRV MNHVNELNGV STKPASAITP ETKSTVNQIM SGGEALAAPV AVPAPIPAPV 900
AEPAPPAAPA KEVVEKAPSP PATRPKSTTP QKFDDDAWAN KPVTEPPVRA SSVTVEPARV 960
TESMNKMNIS EEAKKPEAPS RPRTAPIPEP EEQKKAPVEK KDAEKSVQAP IPAQPTGNIT 1020
IQNAYFTAPQ PMAADPFQSP LYVQPTGFQP PPSALPIQPT GYMQPIPVQA TGYQPLMVQP 1080
TGLQPHMTGV MPQVTGVMPQ MTGVVPQMTG VMPQMTGVQV QKTGAMPQQP VNYGYQVAGM 1140
QPQATGIISQ PTGIRAQATG IMTQPTGLHT QATGMMQPTG MQPQATGIMP QATGMMQPTG 1200
MQPQVTGIMP QSMPMQPQMT GVQVQKTGMV AQPMLSQYTG YQQNYTPTAM PAADGYGMQP 1260
SMNDTQAYYN MNAQTPVNYG FAGGQDTSFG YEQQQMYSPM QQQQQQYYGT EMQPDMGYQQ 1320
PMMSNYYDPM QMQQQTPYGY NQTGMEGYSE YGYAQPAGNM ANPMSYDPVS NASLYMPSDY 1380
NQQTQPANYY DSSFGGAQGA NEAGKKASIY QATPDNPFGF 1421
Keyword

KW-0009--Actin-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR013182--DUF1720
IPR011993--PH/PTB_dom
IPR001452--SH3_domain
IPR007131--SHD1
IPR029922--Sla1
PROSITE

PS50002--SH3
Pfam

PF08226--DUF1720
PF00018--SH3_1
PF14604--SH3_9
PF03983--SHD1
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0032153--C:cell division site
GO:0051286--C:cell tip
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005643--C:nuclear pore
GO:0005886--C:plasma membrane
GO:0000147--P:actin cortical patch assembly
GO:0007015--P:actin filament organization
GO:0006897--P:endocytosis
GO:0071852--P:fungal-type cell wall organization or biogenesis