dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000483
Uniprot Accession O13734; SGO2_SCHPO; Q9UU02;
Genbank Protein ID NP_594301.1;
Genbank Nucleotide ID NM_001019724.2;
Protein Name Shugoshin-2
Protein Synonyms/Alias
Gene Name sgo2
Gene Synonyms/Alias SPAC15A10.15;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
7-MSKASLSPNVEDLKdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
28YKEIIRISKAQSIRIcurated22817900
32IRISKAQSIRIKELQcurated22817900
240NHEYEIVSPKSLSNKdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
292SDTVIQSTPTKRKWDdbPTM 3.0;UniProt18257517; 16381945; 23193290
332SRPNRANSLDSAVLLdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
335NRANSLDSAVLLVQSdbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)		MSKASLSPNV EDLKKKQIRQ YKEIIRISKA QSIRIKELQL ENERLLSENI DLRTTAINLE 60
EQLETVQNEN EENKTKLAAL LNRFHEETDN FLSKLSLCQQ EIQDTFKPVE ANLAYDVDTD 120
SEDLDEESVV KDTEEIIEQA QHDVSLRNLS GIEDENIIDD GETAINEQKK REANVFSDTQ 180
SAPQLKSGKA LPADFENPYN LSNSKPVNNN NEDRVEAVTS ENKSIDSAPQ EKNHEYEIVS 240
PKSLSNKINN QAAAQRRTEE DNANGVAQEE NEGSQEAHFH SRIQSDTVIQ STPTKRKWDV 300
DIQNKQINLA SAATNVTGYV SETDSRPNRA NSLDSAVLLV QSSNKSNRNG HHISDPNLNS 360
SISLKFAPED TAHNSLTSQE NVGPQVTTTS LSNMTVAESP RTDTPREING LVDSSVTNGN 420
EKFSVEIMND SNKIGLNPKS FTDEEREILT LFRNPPMRLS SEPPSSNGFS IAHPNNSPLR 480
PPSLQGILNA EDRPYEIEPS RSSFATNDTG SYNNLELLSS VTNLKSPNEN DRVTKTQSRR 540
ETKVKRRRKA RIQETSEEST VVNEPNEKPD GRSRRERKKV NYALPGLRTK LRRNFDLPSD 600
HVKAKKTRRA PKNSENDSAT KTETANITSE APTTSEVTLE NSETLNL 648
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR011515--Shugoshin_C
IPR011516--Shugoshin_N
PROSITE
Pfam

PF07557--Shugoshin_C
PF07558--Shugoshin_N
Gene Ontology

GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005737--C:cytoplasm
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0072356--P:chromosome passenger complex localization to kinetochore
GO:0045143--P:homologous chromosome segregation
GO:0000070--P:mitotic sister chromatid segregation