dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000453 | ||||||||
| Uniprot Accession | O13539; THP2_YEAST; D3DLB6; | ||||||||
| Genbank Protein ID | NP_012037.1; | ||||||||
| Genbank Nucleotide ID | NM_001179298.1; | ||||||||
| Protein Name | THO complex subunit THP2 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | THP2 | ||||||||
| Gene Synonyms/Alias | YHR167W; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MTKEEGRTYF ESLCEEEQSL QESQTHLLNI LDILSVLADP RSSDDLLTES LKKLPDLHRE 60 LINSSIRLRY DKYQTREAQL LEDTKTGRDV AAGVQNPKSI SEYYSTFEHL NRDTLRYINL 120 LKRLSVDLAK QVEVSDPSVT VYEMDKWVPS EKLQGILEQY CAPDTDIRGV DAQIKNYLDQ 180 IKMARAKFGL ENKYSLKERL STLTKELNHW RKEWDDIEML MFGDDAHSMK KMIQKIDSLK 240 SEINAPSESY PVDKEGDIVL E 262 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR018557--THO_cplx_su_Thp2 |
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| PROSITE | |||||||||
| Pfam | PF09432--THP2 |
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| Gene Ontology | GO:0000446--C:nucleoplasmic THO complex |