dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000448
Uniprot Accession O13370; DED1_SCHPO; O59857; Q9UU14;
Genbank Protein ID NP_588033.1;
Genbank Nucleotide ID NM_001023025.2;
Protein Name ATP-dependent RNA helicase ded1
Protein Synonyms/Alias Multicopy suppressor of overexpressed cyr1 protein 2;
Gene Name ded1
Gene Synonyms/Alias dep1;moc2;sum3;SPCC1795.11;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Inactivation of ded1 blocks mitotic cell cycle progression at G1 and G2/M. Induces sexual development and ascus formation.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
52PAVGDDESVSSRGSSdbPTM 3.0;UniProt18257517; 16381945; 23193290
54VGDDESVSSRGSSRSdbPTM 3.0;UniProt18257517; 16381945; 23193290
55GDDESVSSRGSSRSQdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
58ESVSSRGSSRSQTPSdbPTM 3.0;UniProt18257517; 16381945; 23193290
59SVSSRGSSRSQTPSEdbPTM 3.0;UniProt18257517; 16381945; 23193290
63RGSSRSQTPSEFSSNdbPTM 3.0;UniProt;curated18257517; 16381945; 23193290; 22817900
128HVIGARNTLLERQLFdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
312GCDLLSATPGRLVDLdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
399LSVGRVGSTSENITQdbPTM 3.0;SysPTM 2.0;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MSDNVQQQVD SVGSVTEKLQ KTNISRPRKY IPPFARDKPS AGAAPAVGDD ESVSSRGSSR 60
SQTPSEFSSN YGGRREYNRG GHYGGGEGRQ NNYRGGREGG YSNGGGYRNN RGFGQWRDGQ 120
HVIGARNTLL ERQLFGAVAD GTKVSTGINF EKYDDIPVEV SGGDIEPVNE FTSPPLNSHL 180
LQNIKLSGYT QPTPVQKNSI PIVTSGRDLM ACAQTGSGKT AGFLFPILSL AFDKGPAAVP 240
VDQDAGMGYR PRKAYPTTLI LAPTRELVCQ IHEESRKFCY RSWVRPCAVY GGADIRAQIR 300
QIDQGCDLLS ATPGRLVDLI DRGRISLANI KFLVLDEADR MLDMGFEPQI RHIVEGADMT 360
SVEERQTLMF SATFPRDIQL LARDFLKDYV FLSVGRVGST SENITQKVVH VEDSEKRSYL 420
LDILHTLPPE GLTLIFVETK RMADTLTDYL LNSNFPATSI HGDRTQRERE RALELFRSGR 480
TSIMVATAVA SRGLDIPNVT HVINYDLPTD IDDYVHRIGR TGRAGNTGQA VAFFNRNNKG 540
IAKELIELLQ EANQECPSFL IAMARESSFG GNGRGGRYSG RGGRGGNAYG ARDFRRPTNS 600
SSGYSSGPSY SGYGGFESRT PHHGNTYNSG SAQSWW 637
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0347--Helicase
KW-0378--Hydrolase
KW-0396--Initiation factor
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0694--RNA-binding
Interpro

IPR011545--DEAD/DEAH_box_helicase_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000629--RNA-helicase_DEAD-box_CS
IPR014014--RNA_helicase_DEAD_Q_motif
PROSITE

PS00039--DEAD_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51195--Q_MOTIF
Pfam

PF00270--DEAD
PF00271--Helicase_C
Gene Ontology

GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0003743--F:translation initiation factor activity
GO:0051301--P:cell division
GO:0007059--P:chromosome segregation
GO:0002183--P:cytoplasmic translational initiation
GO:0031047--P:gene silencing by RNA
GO:0007067--P:mitotic nuclear division
GO:0010468--P:regulation of gene expression
GO:0010501--P:RNA secondary structure unwinding