dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000446
Uniprot Accession O13297; CET1_YEAST; D6W3E2; Q12197;
Genbank Protein ID NP_015096.1;
Genbank Nucleotide ID NM_001184042.1;
Protein Name mRNA-capping enzyme subunit beta
Protein Synonyms/Alias Polynucleotide 5'-triphosphatase;mRNA 5'-triphosphatase;TPase;
Gene Name CET1
Gene Synonyms/Alias YPL228W;P1433;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
3-----MSYTDNPPQTcurated26040289
4----MSYTDNPPQTKcurated26040289
10YTDNPPQTKRALSLDcurated26040289
15PQTKRALSLDDLVNHdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 17563356; 18407956; 16381945; 23193290;
49PFAENLESDINQTETcurated22369663; 20377248
121KQHRNLLSNGSPPMNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 19366988; 26447709
124RNLLSNGSPPMNDGSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
144LEKPSDDSIHQNSKSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 25704821;
149DDSIHQNSKSDEEQRPhosphoPep 2.0;curated19060867; 19823750
151SIHQNSKSDEEQRIPPhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;curated21177495; 19823750; 19779198; 19795423; 21081558; 19060867;
352ASLFKELSKYIRGIScurated22817900
354LFKELSKYIRGISEVcurated22817900
449PEKYKSQSPISERTKcurated25315811
Sequence
(Fasta)		MSYTDNPPQT KRALSLDDLV NHDENEKVKL QKLSEAANGS RPFAENLESD INQTETGQAA 60
PIDNYKESTG HGSHSQKPKS RKSSNDDEET DTDDEMGASG EINFDSEMDF DYDKQHRNLL 120
SNGSPPMNDG SDANAKLEKP SDDSIHQNSK SDEEQRIPKQ GNEGNIASNY ITQVPLQKQK 180
QTEKKIAGNA VGSVVKKEEE ANAAVDNIFE EKATLQSKKN NIKRDLEVLN EISASSKPSK 240
YRNVPIWAQK WKPTIKALQS INVKDLKIDP SFLNIIPDDD LTKSVQDWVY ATIYSIAPEL 300
RSFIELEMKF GVIIDAKGPD RVNPPVSSQC VFTELDAHLT PNIDASLFKE LSKYIRGISE 360
VTENTGKFSI IESQTRDSVY RVGLSTQRPR FLRMSTDIKT GRVGQFIEKR HVAQLLLYSP 420
KDSYDVKISL NLELPVPDND PPEKYKSQSP ISERTKDRVS YIHNDSCTRI DITKVENHNQ 480
NSKSRQSETT HEVELEINTP ALLNAFDNIT NDSKEYASLI RTFLNNGTII RRKLSSLSYE 540
IFEGSKKVM
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0506--mRNA capping
KW-0507--mRNA processing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR023577--CYTH-like_domain
IPR004206--mRNA_triPase_Cet1
PROSITE
Pfam

PF02940--mRNA_triPase
Gene Ontology

GO:0031533--C:mRNA cap methyltransferase complex
GO:0004651--F:polynucleotide 5'-phosphatase activity
GO:0006370--P:7-methylguanosine mRNA capping
GO:0098507--P:polynucleotide 5' dephosphorylation
GO:0098501--P:polynucleotide dephosphorylation
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter