dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000445 |
| Uniprot Accession | O13286; SRW1_SCHPO; A7VJ97; |
| Genbank Protein ID | NP_594674.1; |
| Genbank Nucleotide ID | NM_001020103.2; |
| Protein Name | WD repeat-containing protein srw1 |
| Protein Synonyms/Alias | Suppressor of rad/wee1; |
| Gene Name | srw1 |
| Gene Synonyms/Alias | ste9;SPAC144.13c; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MDEFDGFTRP TSSNSSANRN SNNSMNRVEN NNSNSDSANT VDSRGDAHTR MRQGFEKSFP 60 SSPNKKRPRT NEGDRFIPSR DASTELWTGF TKVEGPLTPV KKKQSVADRN FTTLLRSELF 120 GSNDETFNNS PIATPNTTIG VSTPRTDSGI DDIELTQRTP PSSSHTSSSI LQNTPVTPSR 180 KIFHYLSPRD RNKSSYGKKA QYQDNPNRTI YSLSPVRSIT KDLISASRLE GRELPSIPYR 240 VLDAPGLAGD FYLNLLDWGQ CNMLAVALAS RVYLWSGISS EVTVMHNFYP TDTVTSLRWV 300 QRGTHLAVGT HNGSVEIWDA ATCKKTRTMS GHTERVGALS WNDHVLSSGG RDNHILHRDV 360 RAPEHYFRVL TAHRQEVCGL EWNSNENLLA SGGNDNALMV WDKFEEKPLY SFHNHIAAVK 420 AITWSPHQRG ILASGGGTAD RTIKLWNTQR GSMLHNIDTG SQVCNLLWSK QTNEFISTHG 480 FMENEVALWN YPSVSRVGTL KGHTDRVLYL AMSPNGENIV TGAADETLRF WKLFDSKSKH 540 SASTMSSPFD PTMKIR 557 |
| Keyword | KW-0131--Cell cycle |
| Interpro | IPR015943--WD40/YVTN_repeat-like_dom |
| PROSITE | PS00678--WD_REPEATS_1 |
| Pfam | PF00400--WD40 |
| Gene Ontology | GO:0005634--C:nucleus |