| Tag |
Content |
| dbPAF ID |
dbPAF-0000442 |
| Uniprot Accession |
O09175; AMPB_RAT; P97530;
|
| Genbank Protein ID |
NP_112359.1;
|
| Genbank Nucleotide ID |
NM_031097.1;
|
| Protein Name |
Aminopeptidase B |
| Protein Synonyms/Alias |
|
| Gene Name |
Rnpep |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4).Functional Description
Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MESSGPSSCH SAARRPLHSA QAVDVASASS FRAFEILHLH LDLRAEFGPP GPGPGSRGLN 60
GKATLELRCL LPEGASELRL DSHSCLEVMA ATLLRGQPGD QQQLTEPVPF HTQPFSHYGQ 120
ALCVVFPKPC CAAERFRLEL TYRVGEGPGV CWLAPEQTAG KKKPFVYTQG QAVLNRAFFP 180
CFDTPAVKCT YSALVEVPDG FTAVMSASTW ERRGPNKFFF QMSQPIPSYL IALAIGDLAS 240
AEVGPRSRVW AEPCLIEAAK EEYNGVIEEF LATGEKLFGP YVWGRYDLLF MPPSFPFGGM 300
ENPCLTFVTP CLLAGDRSLA DVIIHEISHS WFGNLVTNAN WGEFWLNEGF TMYAQRRIST 360
ILFGAAYTCL EAATGRALLR QHMDVSGEEN PLNKLRVKIE PGVDPDDTYN ETPYEKGYCF 420
VSYLAHLVGD QEQFDKFLKA YVDEFKFQSI LAEDFLEFYL EYFPELKKKG VDSIPGFEFN 480
RWLNTPGWPP YLPDLSPGDS LMKPAEELAE LWAASEPDMQ AIEAVAISTW KTYQLVYFLD 540
KILQKSPLPP GNVKKLGETY PKISNAQNAE LRLRWGQIIL KNDHQEEFWK VKDFLQSQGK 600
QKYTLPLYHA MMGGSEMART LAKETFSATA SQLHSNVVNY VQQILAPKGS
651Fasta Sequence
>O09175|Rnpep|Rattus norvegicus(Rat)
MESSGPSSCHSAARRPLHSAQAVDVASASSFRAFEILHLHLDLRAEFGPPGPGPGSRGLNGKATLELRCLLPEGASELRLDSHSCLEVMAATLLRGQPGDQQQLTEPVPFHTQPFSHYGQALCVVFPKPCCAAERFRLELTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALVEVPDGFTAVMSASTWERRGPNKFFFQMSQPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQEQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFNRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWAASEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDHQEEFWKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKETFSATASQLHSNVVNYVQQILAPKGS
|
| Keyword |
KW-0007--Acetylation
KW-0031--Aminopeptidase
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0964--Secreted
KW-0862--Zinc
|
| Interpro |
IPR016024--ARM-type_fold
IPR015571--Pept_M1_aminopeptidase-B
IPR001930--Peptidase_M1
IPR015211--Peptidase_M1_C
IPR014782--Peptidase_M1_N
|
| PROSITE |
PS00142--ZINC_PROTEASE
|
| Pfam |
PF09127--Leuk-A4-hydro_C
PF01433--Peptidase_M1
|
| Gene Ontology |
GO:0009897--C:external side of plasma membrane
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005794--C:Golgi apparatus
GO:0043005--C:neuron projection
GO:0005886--C:plasma membrane
GO:0030141--C:secretory granule
GO:0004177--F:aminopeptidase activity
GO:0050897--F:cobalt ion binding
GO:0005507--F:copper ion binding
GO:0070006--F:metalloaminopeptidase activity
GO:0042277--F:peptide binding
GO:0008270--F:zinc ion binding
GO:0007568--P:aging
GO:0019370--P:leukotriene biosynthetic process
GO:0045776--P:negative regulation of blood pressure
GO:0043171--P:peptide catabolic process
GO:0016485--P:protein processing
GO:0006508--P:proteolysis
GO:0060041--P:retina development in camera-type eye
|
