Tag |
Content |
dbPAF ID |
dbPAF-0000439 |
Uniprot Accession |
O09172; GSH0_MOUSE;
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Genbank Protein ID |
NP_032155.1;
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Genbank Nucleotide ID |
NM_008129.4;
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Protein Name |
Glutamate--cysteine ligase regulatory subunit |
Protein Synonyms/Alias |
GCS light chain;Gamma-ECS regulatory subunit;Gamma-glutamylcysteine synthetase regulatory subunit;Glutamate--cysteine ligase modifier subunit; |
Gene Name |
Gclm |
Gene Synonyms/Alias |
Glclr; |
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
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Phosphorylation Sites
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dbPAF PTMs: 7 |
Sequence (Fasta) | MGTDSRAAGA LLARASTLHL QTGNLLNWGR LRKKCPSTHS EELRDCIQKT LNEWSSQISP 60 DLVREFPDVL ECTMSHAVEK INPDEREEMK VSAKLFIVGS NSSSSTRSAV DMACSVLGVA 120 QLDSVIMASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ 180 VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIEAQ 240 DWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS
275Fasta Sequence
>O09172|Gclm|Mus musculus(Mouse) MGTDSRAAGALLARASTLHLQTGNLLNWGRLRKKCPSTHSEELRDCIQKTLNEWSSQISPDLVREFPDVLECTMSHAVEKINPDEREEMKVSAKLFIVGSNSSSSTRSAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIEAQDWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
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Keyword |
KW-0007--Acetylation KW-0181--Complete proteome KW-0317--Glutathione biosynthesis KW-0597--Phosphoprotein KW-1185--Reference proteome
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Interpro |
IPR023210--NADP_OxRdtase_dom
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PROSITE |
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Pfam |
PF00248--Aldo_ket_red
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Gene Ontology |
GO:0017109--C:glutamate-cysteine ligase complex GO:0030234--F:enzyme regulator activity GO:0004357--F:glutamate-cysteine ligase activity GO:0035226--F:glutamate-cysteine ligase catalytic subunit binding GO:0046982--F:protein heterodimerization activity GO:0008637--P:apoptotic mitochondrial changes GO:0006534--P:cysteine metabolic process GO:0006536--P:glutamate metabolic process GO:0006750--P:glutathione biosynthetic process GO:0006749--P:glutathione metabolic process GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway GO:0043524--P:negative regulation of neuron apoptotic process GO:0035229--P:positive regulation of glutamate-cysteine ligase activity GO:0050880--P:regulation of blood vessel size GO:0051900--P:regulation of mitochondrial depolarization GO:0042493--P:response to drug GO:0051409--P:response to nitrosative stress GO:0006979--P:response to oxidative stress
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