dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000439
Uniprot Accession O09172; GSH0_MOUSE;
Genbank Protein ID NP_032155.1;
Genbank Nucleotide ID NM_008129.4;
Protein Name Glutamate--cysteine ligase regulatory subunit
Protein Synonyms/Alias GCS light chain;Gamma-ECS regulatory subunit;Gamma-glutamylcysteine synthetase regulatory subunit;Glutamate--cysteine ligase modifier subunit;
Gene Name Gclm
Gene Synonyms/Alias Glclr;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
17ALLARASTLHLQTGNcurated21183079; 23984901
55QKTLNEWSSQISPDLcurated23984901
59NEWSSQISPDLVREFdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated20415495; 21183079; 21659604; 16381945; 23193290; 21081558;
100AKLFIVGSNSSSSTRdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
103FIVGSNSSSSTRSAVdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
105VGSNSSSSTRSAVDMdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
106GSNSSSSTRSAVDMAdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
Sequence
(Fasta)
MGTDSRAAGA LLARASTLHL QTGNLLNWGR LRKKCPSTHS EELRDCIQKT LNEWSSQISP 60
DLVREFPDVL ECTMSHAVEK INPDEREEMK VSAKLFIVGS NSSSSTRSAV DMACSVLGVA 120
QLDSVIMASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ 180
VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIEAQ 240
DWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS 275
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0317--Glutathione biosynthesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR023210--NADP_OxRdtase_dom

PROSITE
Pfam

PF00248--Aldo_ket_red

Gene Ontology

GO:0017109--C:glutamate-cysteine ligase complex
GO:0030234--F:enzyme regulator activity
GO:0004357--F:glutamate-cysteine ligase activity
GO:0035226--F:glutamate-cysteine ligase catalytic subunit binding
GO:0046982--F:protein heterodimerization activity
GO:0008637--P:apoptotic mitochondrial changes
GO:0006534--P:cysteine metabolic process
GO:0006536--P:glutamate metabolic process
GO:0006750--P:glutathione biosynthetic process
GO:0006749--P:glutathione metabolic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0035229--P:positive regulation of glutamate-cysteine ligase activity
GO:0050880--P:regulation of blood vessel size
GO:0051900--P:regulation of mitochondrial depolarization
GO:0042493--P:response to drug
GO:0051409--P:response to nitrosative stress
GO:0006979--P:response to oxidative stress