| Tag |
Content |
| dbPAF ID |
dbPAF-0000438 |
| Uniprot Accession |
O09171; BHMT1_RAT; Q6AZ06;
|
| Genbank Protein ID |
NP_110477.1;
|
| Genbank Nucleotide ID |
NM_030850.1;
|
| Protein Name |
Betaine--homocysteine S-methyltransferase 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
Bhmt |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.Functional Description
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MAPIAGKKAK RGILERLNAG EVVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH 60
REFLRAGSNV MQTFTFYASE DKLENRGNYV AEKISGQKVN EAACDIARQV ADEGDALVAG 120
GVSQTPSYLS CKSETEVKKI FHQQLEVFMK KNVDFLIAEY FEHVEEAVWA VEALKTSGKP 180
IAATMCIGPE GDLHGVSPGE CAVRLVKAGA AIVGVNCHFD PSTSLQTIKL MKEGLEAARL 240
KAYLMSHALA YHTPDCGKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC 300
GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWIRARARKE YWQNLRIASG 360
RPYNPSMSKP DAWGVTKGAA ELMQQKEATT EQQLRALFEK QKFKSAQ
408Fasta Sequence
>O09171|Bhmt|Rattus norvegicus(Rat)
MAPIAGKKAKRGILERLNAGEVVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKIFHQQLEVFMKKNVDFLIAEYFEHVEEAVWAVEALKTSGKPIAATMCIGPEGDLHGVSPGECAVRLVKAGAAIVGVNCHFDPSTSLQTIKLMKEGLEAARLKAYLMSHALAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASGRPYNPSMSKPDAWGVTKGAAELMQQKEATTEQQLRALFEKQKFKSAQ
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
|
| Interpro |
IPR017226--Betaine-hCys_S-MeTrfase_BHMT
IPR003726--HCY_dom
|
| PROSITE |
PS50970--HCY
|
| Pfam |
PF02574--S-methyl_trans
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0043234--C:protein complex
GO:0047150--F:betaine-homocysteine S-methyltransferase activity
GO:0008168--F:methyltransferase activity
GO:0032403--F:protein complex binding
GO:0008898--F:S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0008270--F:zinc ion binding
GO:0006579--P:amino-acid betaine catabolic process
GO:0009086--P:methionine biosynthetic process
GO:0006479--P:protein methylation
GO:0010243--P:response to organonitrogen compound
GO:0033528--P:S-methylmethionine cycle
|
