dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000436
Uniprot Accession O09165; CASQ1_MOUSE;
Genbank Protein ID NP_033943.2;
Genbank Nucleotide ID NM_009813.2;
Protein Name Calsequestrin-1
Protein Synonyms/Alias Calmitine;Calsequestrin, skeletal muscle isoform;
Gene Name Casq1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (By similarity). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
57INVNAKNYKNVFKKYPhosphoSitePlus22135298
71YEVLALLYHEPPEDDPhosphoSitePlus22135298
188KLIGYFKSKDSEHYKPhosphoSitePlus22135298
216PFFATFDSKVAKKLTPhosphoSitePlus22135298
273KLKPESMYETWEDDLPhosphoSitePlus22135298
297EEADPDGYEFLETLKPhosphoSitePlus22135298
302DGYEFLETLKAVAQDPhosphoSitePlus22135298
332DFPLLVPYWEKTFDIPhosphoSitePlus22135298
Sequence
(Fasta)		MRATDRMGAR AVSELRLALL FVLVLGTPRL GVQGEDGLDF PEYDGVDRVI NVNAKNYKNV 60
FKKYEVLALL YHEPPEDDKA SQRQFEMEEL ILELAAQVLE DKGVGFGLVD SEKDAAVAKK 120
LGLTEEDSVY VFKGDEVIEY DGEFSADTLV EFLLDVLEDP VELIEGEREL QAFENIEDEI 180
KLIGYFKSKD SEHYKAYEDA AEEFHPYIPF FATFDSKVAK KLTLKLNEID FYEAFMEEPM 240
TIPDKPNSEE EIVSFVEEHR RSTLRKLKPE SMYETWEDDL DGIHIVAFAE EADPDGYEFL 300
ETLKAVAQDN TENPDLSIIW IDPDDFPLLV PYWEKTFDID LSAPQIGVVN VTDADSIWME 360
MDNEEDLPSA DELEDWLEDV LEGEINTEDD DDDDDDDDDD DDDDD 406
Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0514--Muscle protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0703--Sarcoplasmic reticulum
KW-0732--Signal
Interpro

IPR001393--Calsequestrin
IPR018233--Calsequestrin_CS
IPR012336--Thioredoxin-like_fold
PROSITE

PS00863--CALSEQUESTRIN_1
PS00864--CALSEQUESTRIN_2
Pfam

PF01216--Calsequestrin
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0031674--C:I band
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0016529--C:sarcoplasmic reticulum
GO:0033018--C:sarcoplasmic reticulum lumen
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0030315--C:T-tubule
GO:0014804--C:terminal cisterna lumen
GO:0005509--F:calcium ion binding
GO:0007029--P:endoplasmic reticulum organization
GO:0051258--P:protein polymerization
GO:0006937--P:regulation of muscle contraction
GO:0010880--P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0051282--P:regulation of sequestering of calcium ion
GO:0014809--P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0009408--P:response to heat
GO:0010033--P:response to organic substance
GO:0045214--P:sarcomere organization
GO:0007519--P:skeletal muscle tissue development