| Tag |
Content |
| dbPAF ID |
dbPAF-0000435 |
| Uniprot Accession |
O09161; CASQ2_MOUSE; O88505; Q56A03;
|
| Genbank Protein ID |
NP_033944.2;
|
| Genbank Nucleotide ID |
NM_009814.3;
|
| Protein Name |
Calsequestrin-2 |
| Protein Synonyms/Alias |
Calsequestrin, cardiac muscle isoform; |
| Gene Name |
Casq2 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.Functional Description
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MKRIYLLMVG VYLLSLSGAE EGLNFPTYDG KDRVVSLSEK NLKQMLKRYD LLCLYYHEPV 60
SSDKVSQKQF QLKEIVLELV AQVLEHKNIG FVMVDSRKEA KLAKRLGFSE EGSLYVLKGD 120
RTIEFDGEFA ADVLVEFLLD LIEDPVEIVN NKLEVQAFER IEDQTKLLGF FKNEDSEYYK 180
AFQEAAEHFQ PYIKFFATFD KAVAKKLSLK MNEVGFYEPF MDEPNVIPNK PYTEEELVEF 240
VKEHQRPTLR RLRPEDMFET WEDDLNGIHI VAFAEKSDPD GYEFLEILKQ VARDNTDNPD 300
LSILWIDPDD FPLLVAYWEK TFKIDLFKPQ IGVVNVTDAD SIWMEIPDDD DLPTAEELED 360
WIEDVLSGKI NTEDDDNEDE DDDGDDNDDD DDDDDDNDNS DEDNEDSDDD DDDDE
416Fasta Sequence
>O09161|Casq2|Mus musculus(Mouse)
MKRIYLLMVGVYLLSLSGAEEGLNFPTYDGKDRVVSLSEKNLKQMLKRYDLLCLYYHEPVSSDKVSQKQFQLKEIVLELVAQVLEHKNIGFVMVDSRKEAKLAKRLGFSEEGSLYVLKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIVNNKLEVQAFERIEDQTKLLGFFKNEDSEYYKAFQEAAEHFQPYIKFFATFDKAVAKKLSLKMNEVGFYEPFMDEPNVIPNKPYTEEELVEFVKEHQRPTLRRLRPEDMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFKPQIGVVNVTDADSIWMEIPDDDDLPTAEELEDWIEDVLSGKINTEDDDNEDEDDDGDDNDDDDDDDDDNDNSDEDNEDSDDDDDDDE
|
| Keyword |
KW-0106--Calcium
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0514--Muscle protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0703--Sarcoplasmic reticulum
KW-0732--Signal
|
| Interpro |
IPR001393--Calsequestrin
IPR018233--Calsequestrin_CS
IPR012336--Thioredoxin-like_fold
|
| PROSITE |
PS00863--CALSEQUESTRIN_1
PS00864--CALSEQUESTRIN_2
|
| Pfam |
PF01216--Calsequestrin
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005622--C:intracellular
GO:0030314--C:junctional membrane complex
GO:0016529--C:sarcoplasmic reticulum
GO:0033018--C:sarcoplasmic reticulum lumen
GO:0030018--C:Z disc
GO:0005509--F:calcium ion binding
GO:0048306--F:calcium-dependent protein binding
GO:0060048--P:cardiac muscle contraction
GO:0071313--P:cellular response to caffeine
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:0043267--P:negative regulation of potassium ion transport
GO:0060315--P:negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0051258--P:protein polymerization
GO:0010881--P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010649--P:regulation of cell communication by electrical coupling
GO:0002027--P:regulation of heart rate
GO:0060306--P:regulation of membrane repolarization
GO:0006937--P:regulation of muscle contraction
GO:0010880--P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0045214--P:sarcomere organization
GO:0051208--P:sequestering of calcium ion
|
