dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000434
Uniprot Accession O09159; MA2B1_MOUSE; O55037; Q3UGH3; Q64443; Q9DBQ1;
Genbank Protein ID NP_034894.2;
Genbank Nucleotide ID NM_010764.2;
Protein Name Lysosomal alpha-mannosidase
Protein Synonyms/Alias
Gene Name Man2b1
Gene Synonyms/Alias Laman;Man2b;Manb;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
645VSQGFFWYNASVGDEPhosphoSitePlus22135298
Sequence
(Fasta)		MGTGPLTSGV RAGGGNTGWL WMSSCNLGSP VLPISFLFWL LLAAPGARAA GYKTCPPTKP 60
GMLNVHLLPH THDDVGWLKT VDQYYYGILS DVQHASVQYI LDSVVSSLLE KPTRRFIYVE 120
MAFFSRWWKQ QTSATQDAVR NLVRQGRLEF VNGGWVMNDE AATHYGAIVD QMTLGLRFLQ 180
DTFGSDGLPR VAWHIDPFGH SREQASLFAQ MGFDGFFLGR IDYQDKLNRK KKLRMEELWR 240
ASDSLEPPAA DLFTGVLPNN YNPPKYLCWD VLCTDPPVVD NPRSPEFNAK TLVNYFLKLA 300
SSQKGFYRTN HTVMTMGSDF HYENANMWFK NMDKLIRLVN AQQVNGSLVH VLYSTPTCYL 360
WELNKANLTW TVKEDDFFPY ADGPHMFWTG YFSSRPALKR YERLSYNFLQ VCNQLEALVG 420
PEANVGPYGS GDSAPLQEAM AVLQHHDAVS GTARQNVVND YARQLAAGWG PCEVLVSNAL 480
ARLSHYKQNF SFCRELNISI CPVSQTSERF QVTLYNPLGR KVDQMVRLPV YEGNFIVKDP 540
HDKNISSNVV MVPSYYSETY QWELLFPASV PALGFSTYSV AKMSDLNHQA HNLLSRPRKH 600
KSHHVLVIEN KYMRATFDSG TGLLMKIENL EQNLSLPVSQ GFFWYNASVG DEESSQASGA 660
YIFRPNVGKP IPVSRWAQIS LVKTALVQEV HQNFSAWCSQ VIRLYKGQRH LELEWTVGPI 720
PVRDDWGKEV ISRFDTPMKT KGQFFTDSNG REILKRRDDY RPTWTLNQTE PVAGNYYPVN 780
TRIYITDGQM QLTVLTDRSQ GGSSLQDGSL ELMVHRRLLV DDDRGVSEPL LETDTGDKVR 840
GRHLVLLSSV SDAAARHRLL AEQEVLAPQV VLSLGGSSPY HSRATPKTQF SGLRQELPPQ 900
VHLLTLARWG PKMLLLRLEH QFALKEDSDR NLSSPVTLNV QNLFQTFTIN YLQETTLAAN 960
QPLSRASRLK WMTNTGPTSY PEPSKLDPTS VTLKPMEIRT FLASVQWQEH RPA 1014
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0326--Glycosidase
KW-0378--Hydrolase
KW-0458--Lysosome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0862--Zinc
Interpro

IPR011013--Gal_mutarotase_SF_dom
IPR011330--Glyco_hydro/deAcase_b/a-brl
IPR013780--Glyco_hydro_13_b
IPR027291--Glyco_hydro_38/57_N
IPR011682--Glyco_hydro_38_C
IPR015341--Glyco_hydro_38_cen
IPR000602--Glyco_hydro_38_N
IPR028995--Glyco_hydro_57/38_cen
PROSITE
Pfam

PF09261--Alpha-mann_mid
PF01074--Glyco_hydro_38
PF07748--Glyco_hydro_38C
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005764--C:lysosome
GO:0005774--C:vacuolar membrane
GO:0004559--F:alpha-mannosidase activity
GO:0005537--F:mannose binding
GO:0008270--F:zinc ion binding
GO:0006464--P:cellular protein modification process
GO:0007611--P:learning or memory
GO:0006013--P:mannose metabolic process
GO:0006517--P:protein deglycosylation