dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000432
Uniprot Accession O09130; NF2IP_MOUSE; Q8CDG2; Q9CVY5;
Genbank Protein ID NP_035030.2;
Genbank Nucleotide ID NM_010900.3;
Protein Name NFATC2-interacting protein
Protein Synonyms/Alias 45 kDa NF-AT-interacting protein;45 kDa NFAT-interacting protein;Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein;
Gene Name Nfatc2ip
Gene Synonyms/Alias Nip45;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
49TVLVDLVSDSDEEVLdbPTM 3.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 22135298; 21743459
51LVDLVSDSDEEVLEVdbPTM 3.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 22135298; 21743459
79PAKPEQDSDSDSEGAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 19367708; 16381945; 23193290; 17242355; 18846507;
81KPEQDSDSDSEGAAEdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 19367708; 16381945; 23193290; 17242355; 18846507;
83EQDSDSDSEGAAEGPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 19367708; 16381945; 23193290; 17242355; 18846507;
117EAPVVPVYSGKVQSSPhosphoSitePlus22135298
191EFPDQDISPLPQPSSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 25266776;
227QDLRSCLSPKQHQSPcurated22817900; 21183079
238HQSPALQSTDDEVVLcurated25338131
357KHQMLEISLSPDSPLPhosphoSitePlus22135298
362EISLSPDSPLKVLMSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19854140; 21183079; 16381945; 23193290; 19060867; 22135298;
Sequence
(Fasta)		MAEPLRGRGP RSRGGRGARR ARGARGRCPR ARQSPARLIP DTVLVDLVSD SDEEVLEVAD 60
PVEVPVARLP APAKPEQDSD SDSEGAAEGP AGAPRTLVRR RRRRLLDPGE APVVPVYSGK 120
VQSSLNLIPD NSSLLKLCPS EPEDEADLTN SGSSPSEDDA LPSGSPWRKK LRKKCEKEEK 180
KMEEFPDQDI SPLPQPSSRN KSRKHTEALQ KLREVNKRLQ DLRSCLSPKQ HQSPALQSTD 240
DEVVLVEGPV LPQSSRLFTL KIRCRADLVR LPVRMSEPLQ NVVDHMANHL GVSPNRILLL 300
FGESELSPTA TPSTLKLGVA DIIDCVVLAS SSEATETSQE LRLRVQGKEK HQMLEISLSP 360
DSPLKVLMSH YEEAMGLSGH KLSFFFDGTK LSGKELPADL GLESGDLIEV WG 413
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR022617--Rad60/SUMO-like_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF11976--Rad60-SLD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031386--F:protein tag
GO:0001816--P:cytokine production
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016925--P:protein sumoylation