| Tag |
Content |
| dbPAF ID |
dbPAF-0000430 |
| Uniprot Accession |
O09126; SEM4D_MOUSE; Q6GTM9;
|
| Genbank Protein ID |
NP_001268809.1; NP_038688.2; XP_006516946.1; XP_006516947.1; XP_006516948.1; XP_006516949.1; XP_006516950.1; XP_006516951.1;
|
| Genbank Nucleotide ID |
NM_001281880.1; NM_013660.4; XM_006516883.2; XM_006516884.2; XM_006516885.2; XM_006516886.2; XM_006516887.2; XM_006516888.2;
|
| Protein Name |
Semaphorin-4D |
| Protein Synonyms/Alias |
M-Sema G;Semaphorin-C-like 2;Semaphorin-J;Sema J; |
| Gene Name |
Sema4d |
| Gene Synonyms/Alias |
Semacl2;Semaj; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).Functional Description
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MRMCAPVRGL FLALVVVLRT AVAFAPVPRL TWEHGEVGLV QFHKPGIFNY SALLMSEDKD 60
TLYVGAREAV FAVNALNISE KQHEVYWKVS EDKKSKCAEK GKSKQTECLN YIRVLQPLSS 120
TSLYVCGTNA FQPTCDHLNL TSFKFLGKSE DGKGRCPFDP AHSYTSVMVG GELYSGTSYN 180
FLGSEPIISR NSSHSPLRTE YAIPWLNEPS FVFADVIQKS PDGPEGEDDK VYFFFTEVSV 240
EYEFVFKLMI PRVARVCKGD QGGLRTLQKK WTSFLKARLI CSKPDSGLVF NILQDVFVLR 300
APGLKEPVFY AVFTPQLNNV GLSAVCAYTL ATVEAVFSRG KYMQSATVEQ SHTKWVRYNG 360
PVPTPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM DDSVTPIDNR PKLIKKDVNY 420
TQIVVDRTQA LDGTFYDVMF ISTDRGALHK AVILTKEVHV IEETQLFRDS EPVLTLLLSS 480
KKGRKFVYAG SNSGVVQAPL AFCEKHGSCE DCVLARDPYC AWSPAIKACV TLHQEEASSR 540
GWIQDMSGDT SSCLDKSKES FNQHFFKHGG TAELKCFQKS NLARVVWKFQ NGELKAASPK 600
YGFVGRKHLL IFNLSDGDSG VYQCLSEERV RNKTVSQLLA KHVLEVKMVP RTPPSPTSED 660
AQTEGSKITS KMPVASTQGS SPPTPALWAT SPRAATLPPK SSSGTSCEPK MVINTVPQLH 720
SEKTVYLKSS DNRLLMSLLL FIFVLFLCLF SYNCYKGYLP GQCLKFRSAL LLGKKTPKSD 780
FSDLEQSVKE TLVEPGSFSQ QNGDHPKPAL DTGYETEQDT ITSKVPTDRE DSQRIDELSA 840
RDKPFDVKCE LKFADSDADG D
862Fasta Sequence
>O09126|Sema4d|Mus musculus(Mouse)
MRMCAPVRGLFLALVVVLRTAVAFAPVPRLTWEHGEVGLVQFHKPGIFNYSALLMSEDKDTLYVGAREAVFAVNALNISEKQHEVYWKVSEDKKSKCAEKGKSKQTECLNYIRVLQPLSSTSLYVCGTNAFQPTCDHLNLTSFKFLGKSEDGKGRCPFDPAHSYTSVMVGGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIQKSPDGPEGEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGGLRTLQKKWTSFLKARLICSKPDSGLVFNILQDVFVLRAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLATVEAVFSRGKYMQSATVEQSHTKWVRYNGPVPTPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPKLIKKDVNYTQIVVDRTQALDGTFYDVMFISTDRGALHKAVILTKEVHVIEETQLFRDSEPVLTLLLSSKKGRKFVYAGSNSGVVQAPLAFCEKHGSCEDCVLARDPYCAWSPAIKACVTLHQEEASSRGWIQDMSGDTSSCLDKSKESFNQHFFKHGGTAELKCFQKSNLARVVWKFQNGELKAASPKYGFVGRKHLLIFNLSDGDSGVYQCLSEERVRNKTVSQLLAKHVLEVKMVPRTPPSPTSEDAQTEGSKITSKMPVASTQGSSPPTPALWATSPRAATLPPKSSSGTSCEPKMVINTVPQLHSEKTVYLKSSDNRLLMSLLLFIFVLFLCLFSYNCYKGYLPGQCLKFRSALLLGKKTPKSDFSDLEQSVKETLVEPGSFSQQNGDHPKPALDTGYETEQDTITSKVPTDREDSQRIDELSARDKPFDVKCELKFADSDADGD
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR013151--Immunoglobulin
IPR016201--Plexin-like_fold
IPR002165--Plexin_repeat
IPR001627--Semap_dom
IPR027231--Semaphorin
IPR015943--WD40/YVTN_repeat-like_dom
|
| PROSITE |
PS50835--IG_LIKE
PS51004--SEMA
|
| Pfam |
PF00047--ig
PF01437--PSI
PF01403--Sema
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0045499--F:chemorepellent activity
GO:0004872--F:receptor activity
GO:0005102--F:receptor binding
GO:0030215--F:semaphorin receptor binding
GO:0004888--F:transmembrane signaling receptor activity
GO:0070486--P:leukocyte aggregation
GO:0050919--P:negative chemotaxis
GO:0010693--P:negative regulation of alkaline phosphatase activity
GO:0048843--P:negative regulation of axon extension involved in axon guidance
GO:0007162--P:negative regulation of cell adhesion
GO:0045668--P:negative regulation of osteoblast differentiation
GO:0050732--P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001755--P:neural crest cell migration
GO:0043931--P:ossification involved in bone maturation
GO:0050772--P:positive regulation of axonogenesis
GO:0030335--P:positive regulation of cell migration
GO:0048672--P:positive regulation of collateral sprouting
GO:0043547--P:positive regulation of GTPase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0001934--P:positive regulation of protein phosphorylation
GO:0031344--P:regulation of cell projection organization
GO:0008360--P:regulation of cell shape
GO:0048814--P:regulation of dendrite morphogenesis
GO:0071526--P:semaphorin-plexin signaling pathway
GO:1900220--P:semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
|
