dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000428
Uniprot Accession O09112; DUS8_MOUSE;
Genbank Protein ID NP_032774.1; XP_006508572.1; XP_011240291.1;
Genbank Nucleotide ID NM_008748.3; XM_006508509.2; XM_011241989.1;
Protein Name Dual specificity protein phosphatase 8
Protein Synonyms/Alias
Gene Name Dusp8
Gene Synonyms/Alias Nttp1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
397NRLKRSFSLDIKSAYdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 21743459;
515GWVPPLDSPGTPSPDdbPTM 3.0;PhosphoSitePlus22100391; 16381945; 23193290; 22135298
518PPLDSPGTPSPDGPWdbPTM 3.0;PhosphoSitePlus22100391; 16381945; 23193290; 22135298
520LDSPGTPSPDGPWCFdbPTM 3.0;PhosphoSitePlus22100391; 16381945; 23193290; 22135298
595SSSSSSSSSSSSSDLPhosphoSitePlus22135298
596SSSSSSSSSSSSDLRPhosphoSitePlus;curated22135298; 22817900
599SSSSSSSSSDLRRRDPhosphoSitePlus22135298
600SSSSSSSSDLRRRDVPhosphoSitePlus22135298
Sequence
(Fasta)		MAGDRLPRKV MDAKKLASLL RGGPGGPLVI DSRSFVEYNS CHVLSSVNIC CSKLVKRRLQ 60
QGKVTIAELI QPATRSQVDA TEPQDVVVYD QSTRDASVLA ADSFLSILLS KLDGCFDSVA 120
ILTGGFATFS SCFPGLCEGK PATLPSMSLS QPCLPVPSVG LTRILPHLYL GSQKDVLNKD 180
LMTQNGISYV LNASNSCPKP DFICESRFMR IPINDNYCEK LLPWLDKSIE FIDKAKLSSC 240
QVIVHCLAGI SRSATIAIAY IMKTMGMSSD DAYRFVKDRR PSISPNFNFL GQLLEYERSL 300
KLLAALQTDG PHLGTPEPLM GPAAGIPLPR LPPSTSESAA TGSEAATAAR EGSPSAGGDA 360
PIPSTAPATS ALQQGLRGLH LSSDRLQDTN RLKRSFSLDI KSAYAPSRRP DFPGPPDPGE 420
APKLCKLDSP SGGTLGLPSP SPDSPDSVPE CRPRPRRRRP PASSPARSPA HGLGLNFGDT 480
ARQTPRHGLS ALSAPGLPGP GQPAGPGGWV PPLDSPGTPS PDGPWCFSPE GAQGPGAVFS 540
AFGRVSAGAP GPGNSSSSGG GGGGGGGGGG GGGGGGSSSS NSSSSSSSSS SSSSSSSSSS 600
DLRRRDVRTG WPEEPAADAQ FKRRSCQMEF EEGMVEGRAR GEELAALGKQ TSFSGSVEVI 660
EVS 664
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0904--Protein phosphatase
KW-1185--Reference proteome
Interpro

IPR000340--Dual-sp_phosphatase_cat-dom
IPR024950--DUSP
IPR008343--MKP
IPR029021--Prot-tyrosine_phosphatase-like
IPR001763--Rhodanese-like_dom
IPR016130--Tyr_Pase_AS
IPR000387--TYR_PHOSPHATASE_dom
IPR020422--TYR_PHOSPHATASE_DUAL_dom
PROSITE

PS50206--RHODANESE_3
PS00383--TYR_PHOSPHATASE_1
PS50056--TYR_PHOSPHATASE_2
PS50054--TYR_PHOSPHATASE_DUAL
Pfam

PF00782--DSPc
PF00581--Rhodanese
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0017017--F:MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0004725--F:protein tyrosine phosphatase activity
GO:0008138--F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470--P:protein dephosphorylation