dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000426
Uniprot Accession O09110; MP2K3_MOUSE; P97293; Q91VX1;
Genbank Protein ID NP_032954.1;
Genbank Nucleotide ID NM_008928.4;
Protein Name Dual specificity mitogen-activated protein kinase kinase 3
Protein Synonyms/Alias
Gene Name Map2k3
Gene Synonyms/Alias Mkk3;Prkmk3;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity).
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
3-----MESPAASPPAcurated25338131
7-MESPAASPPASLPQcurated25338131
28RKKDLRISCVSKPPVPhosphoSitePlus22135298
31DLRISCVSKPPVSNPPhosphoSitePlus22135298
218ISGYLVDSVAKTMDAdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 22322096; 16381945; 23193290; 19060867; 22135298;
222LVDSVAKTMDAGCKPPhosphoPep 2.0;curated19060867; 21183079
Sequence
(Fasta)
MESPAASPPA SLPQTKGKSK RKKDLRISCV SKPPVSNPTP PRNLDSRTFI TIGDRNFEVE 60
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN TQEQKRLLMD LDINMRTVDC 120
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLEKNMK IPEDILGEIA VSIVRALEHL 180
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 240
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD 300
FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS 348
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005524--F:ATP binding
GO:0004708--F:MAP kinase kinase activity
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0000187--P:activation of MAPK activity
GO:0060048--P:cardiac muscle contraction
GO:0006954--P:inflammatory response
GO:0000165--P:MAPK cascade
GO:0045860--P:positive regulation of protein kinase activity
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0042981--P:regulation of apoptotic process
GO:0042035--P:regulation of cytokine biosynthetic process
GO:0007346--P:regulation of mitotic cell cycle
GO:0031098--P:stress-activated protein kinase signaling cascade