Tag |
Content |
dbPAF ID |
dbPAF-0000426 |
Uniprot Accession |
O09110; MP2K3_MOUSE; P97293; Q91VX1; |
Genbank Protein ID |
NP_032954.1; |
Genbank Nucleotide ID |
NM_008928.4; |
Protein Name |
Dual specificity mitogen-activated protein kinase kinase 3 |
Protein Synonyms/Alias |
|
Gene Name |
Map2k3 |
Gene Synonyms/Alias |
Mkk3;Prkmk3; |
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity).Functional Description
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity).
|
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence (Fasta) | MESPAASPPA SLPQTKGKSK RKKDLRISCV SKPPVSNPTP PRNLDSRTFI TIGDRNFEVE 60 ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN TQEQKRLLMD LDINMRTVDC 120 FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLEKNMK IPEDILGEIA VSIVRALEHL 180 HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 240 NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD 300 FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
348Fasta Sequence
>O09110|Map2k3|Mus musculus(Mouse) MESPAASPPASLPQTKGKSKRKKDLRISCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
|
Keyword |
KW-0002--3D-structure KW-0007--Acetylation KW-0025--Alternative splicing KW-0067--ATP-binding KW-0181--Complete proteome KW-0418--Kinase KW-0547--Nucleotide-binding KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0723--Serine/threonine-protein kinase KW-0808--Transferase KW-0829--Tyrosine-protein kinase
|
Interpro |
IPR011009--Kinase-like_dom IPR000719--Prot_kinase_dom IPR017441--Protein_kinase_ATP_BS IPR002290--Ser/Thr_dual-sp_kinase IPR008271--Ser/Thr_kinase_AS
|
PROSITE |
PS00107--PROTEIN_KINASE_ATP PS50011--PROTEIN_KINASE_DOM PS00108--PROTEIN_KINASE_ST
|
Pfam |
PF00069--Pkinase
|
Gene Ontology |
GO:0005737--C:cytoplasm GO:0016020--C:membrane GO:0005524--F:ATP binding GO:0004708--F:MAP kinase kinase activity GO:0019901--F:protein kinase binding GO:0004674--F:protein serine/threonine kinase activity GO:0004713--F:protein tyrosine kinase activity GO:0000187--P:activation of MAPK activity GO:0060048--P:cardiac muscle contraction GO:0006954--P:inflammatory response GO:0000165--P:MAPK cascade GO:0045860--P:positive regulation of protein kinase activity GO:0045893--P:positive regulation of transcription, DNA-templated GO:0042981--P:regulation of apoptotic process GO:0042035--P:regulation of cytokine biosynthetic process GO:0007346--P:regulation of mitotic cell cycle GO:0031098--P:stress-activated protein kinase signaling cascade
|