Functional Description
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. |
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000792--C:heterochromatin
GO:0000118--C:histone deacetylase complex
GO:0043025--C:neuronal cell body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0043234--C:protein complex
GO:0016580--C:Sin3 complex
GO:0005667--C:transcription factor complex
GO:0017053--C:transcriptional repressor complex
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0019213--F:deacetylase activity
GO:0003677--F:DNA binding
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0035851--F:Krueppel-associated box domain binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051059--F:NF-kappaB binding
GO:0033558--F:protein deacetylase activity
GO:0047485--F:protein N-terminus binding
GO:0070491--F:repressing transcription factor binding
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0016568--P:chromatin modification
GO:0000183--P:chromatin silencing at rDNA
GO:0032922--P:circadian regulation of gene expression
GO:0007623--P:circadian rhythm
GO:0042733--P:embryonic digit morphogenesis
GO:0007492--P:endoderm development
GO:0009913--P:epidermal cell differentiation
GO:0061029--P:eyelid development in camera-type eye
GO:0061198--P:fungiform papilla formation
GO:0060789--P:hair follicle placode formation
GO:0021766--P:hippocampus development
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0043922--P:negative regulation by host of viral transcription
GO:0060766--P:negative regulation of androgen receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0010629--P:negative regulation of gene expression
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030182--P:neuron differentiation
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0008284--P:positive regulation of cell proliferation
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006476--P:protein deacetylation
GO:0006351--P:transcription, DNA-templated
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