Tag |
Content |
dbPAF ID |
dbPAF-0000424 |
Uniprot Accession |
O09100; GATA2_MOUSE; |
Genbank Protein ID |
NP_032116.4; XP_006505602.1; |
Genbank Nucleotide ID |
NM_008090.5; XM_006505539.2; |
Protein Name |
Endothelial transcription factor GATA-2 |
Protein Synonyms/Alias |
GATA-binding protein 2; |
Gene Name |
Gata2 |
Gene Synonyms/Alias |
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Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.Functional Description
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
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Phosphorylation Sites
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dbPAF PTMs: 3 |
Sequence (Fasta) | MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 60 ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP 120 FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 180 VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP 240 ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 300 TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 360 RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC 420 MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG 480
481Fasta Sequence
>O09100|Gata2|Mus musculus(Mouse) MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYGSSLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSPPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG
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Keyword |
KW-0010--Activator KW-0181--Complete proteome KW-0238--DNA-binding KW-0479--Metal-binding KW-0539--Nucleus KW-0581--Phagocytosis KW-1185--Reference proteome KW-0677--Repeat KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc KW-0863--Zinc-finger
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Interpro |
IPR029522--GATA-2 IPR016374--TF_GATA-2/3 IPR000679--Znf_GATA IPR013088--Znf_NHR/GATA
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PROSITE |
PS00344--GATA_ZN_FINGER_1 PS50114--GATA_ZN_FINGER_2
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Pfam |
PF00320--GATA
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Gene Ontology |
GO:0005829--C:cytosol GO:0042629--C:mast cell granule GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0043234--C:protein complex GO:0005667--C:transcription factor complex GO:0070742--F:C2H2 zinc finger domain binding GO:0003682--F:chromatin binding GO:0003677--F:DNA binding GO:0001158--F:enhancer sequence-specific DNA binding GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001085--F:RNA polymerase II transcription factor binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0008134--F:transcription factor binding GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0008270--F:zinc ion binding GO:0030154--P:cell differentiation GO:0021533--P:cell differentiation in hindbrain GO:0001709--P:cell fate determination GO:0048469--P:cell maturation GO:0021954--P:central nervous system neuron development GO:0021902--P:commitment of neuronal cell to specific neuron type in forebrain GO:0060216--P:definitive hemopoiesis GO:0048565--P:digestive tract development GO:0001892--P:embryonic placenta development GO:0035854--P:eosinophil fate commitment GO:0097154--P:GABAergic neuron differentiation GO:0007507--P:heart development GO:0048873--P:homeostasis of number of cells within a tissue GO:0042472--P:inner ear morphogenesis GO:0043303--P:mast cell degranulation GO:0045599--P:negative regulation of fat cell differentiation GO:0070345--P:negative regulation of fat cell proliferation GO:0045650--P:negative regulation of macrophage differentiation GO:0045638--P:negative regulation of myeloid cell differentiation GO:2000178--P:negative regulation of neural precursor cell proliferation GO:0045746--P:negative regulation of Notch signaling pathway GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0030182--P:neuron differentiation GO:0048663--P:neuron fate commitment GO:0001764--P:neuron migration GO:0006909--P:phagocytosis GO:0021983--P:pituitary gland development GO:0045766--P:positive regulation of angiogenesis GO:0007204--P:positive regulation of cytosolic calcium ion concentration GO:0045648--P:positive regulation of erythrocyte differentiation GO:0045654--P:positive regulation of megakaryocyte differentiation GO:0045666--P:positive regulation of neuron differentiation GO:0050766--P:positive regulation of phagocytosis GO:0060100--P:positive regulation of phagocytosis, engulfment GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:2000977--P:regulation of forebrain neuron differentiation GO:0035065--P:regulation of histone acetylation GO:0033993--P:response to lipid GO:0060872--P:semicircular canal development GO:0035019--P:somatic stem cell population maintenance GO:0009888--P:tissue development GO:0006366--P:transcription from RNA polymerase II promoter GO:0006351--P:transcription, DNA-templated GO:0001655--P:urogenital system development GO:0021514--P:ventral spinal cord interneuron differentiation
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