dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000424
Uniprot Accession O09100; GATA2_MOUSE;
Genbank Protein ID NP_032116.4; XP_006505602.1;
Genbank Nucleotide ID NM_008090.5; XM_006505539.2;
Protein Name Endothelial transcription factor GATA-2
Protein Synonyms/Alias GATA-binding protein 2;
Gene Name Gata2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
73ARARVSYSPAHARLTdbPTM 3.0;PhosphoSitePlus;curated19854140; 16381945; 23193290; 22135298; 22817900
192PSTTGAASPASSSAGdbPTM 3.0;PhosphoSitePlus;curated19854140; 16381945; 23193290; 22135298; 22817900; 25338131
401QTRNRKMSSKSKKSKPhosphoSitePlus;curated22135298; 22817900
Sequence
(Fasta)
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 60
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP 120
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 180
VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP 240
ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 300
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 360
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC 420
MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG 480
481
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0581--Phagocytosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029522--GATA-2
IPR016374--TF_GATA-2/3
IPR000679--Znf_GATA
IPR013088--Znf_NHR/GATA

PROSITE

PS00344--GATA_ZN_FINGER_1
PS50114--GATA_ZN_FINGER_2

Pfam

PF00320--GATA

Gene Ontology

GO:0005829--C:cytosol
GO:0042629--C:mast cell granule
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0005667--C:transcription factor complex
GO:0070742--F:C2H2 zinc finger domain binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0001158--F:enhancer sequence-specific DNA binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0021533--P:cell differentiation in hindbrain
GO:0001709--P:cell fate determination
GO:0048469--P:cell maturation
GO:0021954--P:central nervous system neuron development
GO:0021902--P:commitment of neuronal cell to specific neuron type in forebrain
GO:0060216--P:definitive hemopoiesis
GO:0048565--P:digestive tract development
GO:0001892--P:embryonic placenta development
GO:0035854--P:eosinophil fate commitment
GO:0097154--P:GABAergic neuron differentiation
GO:0007507--P:heart development
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0042472--P:inner ear morphogenesis
GO:0043303--P:mast cell degranulation
GO:0045599--P:negative regulation of fat cell differentiation
GO:0070345--P:negative regulation of fat cell proliferation
GO:0045650--P:negative regulation of macrophage differentiation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182--P:neuron differentiation
GO:0048663--P:neuron fate commitment
GO:0001764--P:neuron migration
GO:0006909--P:phagocytosis
GO:0021983--P:pituitary gland development
GO:0045766--P:positive regulation of angiogenesis
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0045648--P:positive regulation of erythrocyte differentiation
GO:0045654--P:positive regulation of megakaryocyte differentiation
GO:0045666--P:positive regulation of neuron differentiation
GO:0050766--P:positive regulation of phagocytosis
GO:0060100--P:positive regulation of phagocytosis, engulfment
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000977--P:regulation of forebrain neuron differentiation
GO:0035065--P:regulation of histone acetylation
GO:0033993--P:response to lipid
GO:0060872--P:semicircular canal development
GO:0035019--P:somatic stem cell population maintenance
GO:0009888--P:tissue development
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0001655--P:urogenital system development
GO:0021514--P:ventral spinal cord interneuron differentiation