dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000423
Uniprot Accession O09061; PSB1_MOUSE; Q62038; Q62039;
Genbank Protein ID NP_035315.1;
Genbank Nucleotide ID NM_011185.3;
Protein Name Proteasome subunit beta type-1
Protein Synonyms/Alias Macropain subunit C5;Multicatalytic endopeptidase complex subunit C5;Proteasome component C5;Proteasome gamma chain;
Gene Name Psmb1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
48AIAGEDFSIVASDTRPhosphoSitePlus22135298
52EDFSIVASDTRLSEGPhosphoSitePlus22135298
67FSIHTRDSPKCYKLTcurated25338131
149EEGKGAVYSFDPVGSdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18034455; 16381945; 23193290; 18563927; 20415495; 21081558;
157SFDPVGSYQRDSFKAPHOSIDA21081558
167DSFKAGGSASAMLQPdbPTM 3.0;SysPTM 2.018579562; 16381945; 23193290; 19366988
194NVEHVPLTLDRAMRLPhosphoSitePlus22135298
208LVKDVFISAAERDVYPhosphoSitePlus22135298
215SAAERDVYTGDALRIdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated18563927; 16381945; 23193290; 22135298; 19366988; 22817900
Sequence
(Fasta)		MLSTAAYRDV ERELGMGPHG SAGPVQLRFS PYAFNGGTVL AIAGEDFSIV ASDTRLSEGF 60
SIHTRDSPKC YKLTDKTVIG CSGFHGDCLT LTKIIEARLK MYKHSNNKAM TTGAIAAMLS 120
TILYSRRFFP YYVYNIIGGL DEEGKGAVYS FDPVGSYQRD SFKAGGSASA MLQPLLDNQV 180
GFKNMQNVEH VPLTLDRAMR LVKDVFISAA ERDVYTGDAL RICIVTKEGI REETVPLRKD 240
241
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0888--Threonine protease
Interpro

IPR029055--Ntn_hydrolases_N
IPR016050--Proteasome_bsu_CS
IPR001353--Proteasome_sua/b
IPR023333--Proteasome_suB-type
PROSITE

PS00854--PROTEASOME_BETA_1
PS51476--PROTEASOME_BETA_2
Pfam

PF00227--Proteasome
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0005839--C:proteasome core complex
GO:0004175--F:endopeptidase activity
GO:0004298--F:threonine-type endopeptidase activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process