dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000419
Uniprot Accession O09039; SH2B3_MOUSE;
Genbank Protein ID NP_001293055.1; NP_001293056.1; NP_032533.1; XP_006530233.1; XP_006530234.1; XP_006530235.1; XP_006530236.1; XP_011246484.1; XP_011246485.1;
Genbank Nucleotide ID NM_001306126.1; NM_001306127.1; NM_008507.4; XM_006530170.2; XM_006530171.2; XM_006530172.1; XM_006530173.2; XM_011248182.1; XM_011248183.1;
Protein Name SH2B adapter protein 3
Protein Synonyms/Alias Lymphocyte adapter protein;Lymphocyte-specific adapter protein Lnk;Signal transduction protein Lnk;
Gene Name Sh2b3
Gene Synonyms/Alias Lnk;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
13VQPSRTSSAPASPASdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
17RTSSAPASPASPRGWPhosphoSitePlus;curated22135298; 23567750
102PALPKARSSEDLGPRcurated21743459; 23984901; 25338131
103ALPKARSSEDLGPRPcurated21183079; 25338131
129RQLFRRRSAGELPGAdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19854140; 20531401; 21183079; 16381945; 23193290; 21081558;
287LGLEHPDTELPLSLAdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298; 22817900
302AEPGPARSPRGSTDSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900;
517SVSSARDSDYDMDSSdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
523DSDYDMDSSSRGHLRdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
525DYDMDSSSRGHLRAIdbPTM 3.0;PhosphoSitePlus20139300; 16381945; 23193290; 22135298
536LRAIDNQYTPLSQLCdbPTM 3.0;PhosphoSitePlus;curated18753636; 9169414; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MNEPTVQPSR TSSAPASPAS PRGWSDFCEQ HAAAAARELA RQYWLFARAH PQPPRADLVS 60
LQFAELFQRH FCREVRESLA GPPGHDYRAT APPRPALPKA RSSEDLGPRP ACALQHLRRG 120
LRQLFRRRSA GELPGATSDT NDIDTTAASR PGPARKLLPW GLREPPTEAL KEVVLRYSLA 180
DEAAMDSGAR WQRGRLVLRS PGPGHSHFLQ LFDPPKSSKP KLQEACSSIR EVRPCTRLEM 240
PDNLYTFVLK VQDQTDIIFE VGDEQQLNSW LAELRASTGL GLEHPDTELP LSLAAEPGPA 300
RSPRGSTDSL DQGASPGVLL DPACQKTDHF LSCYPWFHGP ISRVRAAQLV QLQGPDAHGV 360
FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH LHFPSVVDML RHFQRSPIPL 420
ECGAACDVRL SGYVVVLSQA PGSSNTVLFP FSLPHWDSEL GHPHLSSVGC PPSHGAEALP 480
GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYD MDSSSRGHLR AIDNQYTPLS 540
QLCREADV 549
Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
Interpro

IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR015012--Phe_ZIP
IPR000980--SH2
IPR030523--SH2B
IPR030522--SH2B3
PROSITE

PS50001--SH2
Pfam

PF08916--Phe_ZIP
PF00017--SH2
Gene Ontology

GO:0005622--C:intracellular
GO:0042301--F:phosphate ion binding
GO:0004871--F:signal transducer activity
GO:0035591--F:signaling adaptor activity
GO:0030154--P:cell differentiation
GO:0035162--P:embryonic hemopoiesis
GO:0030097--P:hemopoiesis
GO:0035556--P:intracellular signal transduction