dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000414
Uniprot Accession O09012; PEX5_MOUSE; Q3UM58; Q8K2V5; Q91YC7;
Genbank Protein ID NP_001264259.1; NP_001264734.1; NP_033021.2; NP_787947.1; XP_006505821.1; XP_006505822.1;
Genbank Nucleotide ID NM_001277330.1; NM_001277805.1; NM_008995.2; NM_175933.2; XM_006505758.2; XM_006505759.2;
Protein Name Peroxisomal targeting signal 1 receptor
Protein Synonyms/Alias
Gene Name Pex5
Gene Synonyms/Alias Pxr1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
155VTDPLSVSPARWAEEcurated25338131
167AEEYLEQSEEKLWLGcurated25338131
179WLGDQEGSSTADRWYPhosphoSitePlus;curated22135298; 21743459; 23567750; 25338131
281VEFERAKSAIESDVDPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 20469934; 25338131
285RAKSAIESDVDFWDKPhosphoSitePlus22135298
312AEAHPWLSDYDDLTSPhosphoSitePlus;curated22135298; 25338131
319SDYDDLTSASYDKGYPhosphoSitePlus;curated22135298; 25338131
427LQRQACETLRDWLRYPhosphoSitePlus22135298
Sequence
(Fasta)		MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV SKPLGVGTED 60
ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR QAPQRAPGVA DLALSENWAQ 120
EFLAAGDAVD VAQDYNETDW SQEFIAEVTD PLSVSPARWA EEYLEQSEEK LWLGDQEGSS 180
TADRWYDEYH PEEDLQHTAS DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ 240
AEQWAAEFIQ QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM 300
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE GDLPNAVLLF 360
EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL KPDNRTALMA LAVSFTNESL 420
QRQACETLRD WLRYSPAYAH LVAPGEEGAT GAGPSKRILG SLLSDSLFLE VKDLFLAAVR 480
LDPTSIDPDV QCGLGVLFNL SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE 540
AVAAYRRALE LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 600
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0882--Thioester bond
KW-0802--TPR repeat
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR024111--PTS1R_family
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00515--TPR_1
PF13414--TPR_11
PF13181--TPR_8
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005782--C:peroxisomal matrix
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0043234--C:protein complex
GO:0019899--F:enzyme binding
GO:0005052--F:peroxisome matrix targeting signal-1 binding
GO:0000268--F:peroxisome targeting sequence binding
GO:0008022--F:protein C-terminus binding
GO:0047485--F:protein N-terminus binding
GO:0031267--F:small GTPase binding
GO:0048468--P:cell development
GO:0044255--P:cellular lipid metabolic process
GO:0021795--P:cerebral cortex cell migration
GO:0021895--P:cerebral cortex neuron differentiation
GO:0007029--P:endoplasmic reticulum organization
GO:0006635--P:fatty acid beta-oxidation
GO:0007006--P:mitochondrial membrane organization
GO:0007005--P:mitochondrion organization
GO:1901094--P:negative regulation of protein homotetramerization
GO:0050905--P:neuromuscular process
GO:0001764--P:neuron migration
GO:0007031--P:peroxisome organization
GO:0040018--P:positive regulation of multicellular organism growth
GO:0016558--P:protein import into peroxisome matrix
GO:0016560--P:protein import into peroxisome matrix, docking
GO:0016561--P:protein import into peroxisome matrix, translocation
GO:0045046--P:protein import into peroxisome membrane
GO:0006625--P:protein targeting to peroxisome
GO:0051262--P:protein tetramerization
GO:0000038--P:very long-chain fatty acid metabolic process