| Tag |
Content |
| dbPAF ID |
dbPAF-0000413 |
| Uniprot Accession |
O09010; LFNG_MOUSE; Q3U659; Q8K3F1; Q9DC10;
|
| Genbank Protein ID |
NP_032520.1;
|
| Genbank Nucleotide ID |
NM_008494.3;
|
| Protein Name |
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe |
| Protein Synonyms/Alias |
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; |
| Gene Name |
Lfng |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules inhibiting Jagged mediated Notch signaling. Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-formig territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity. Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors. May play a role in boundary formation of the enamel knot.Functional Description
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules inhibiting Jagged mediated Notch signaling. Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-formig territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity. Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors. May play a role in boundary formation of the enamel knot. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MLQRCGRRLL LALVGALLAC LLVLTADPPP TPMPAERGRR ALRSLAGSSG GAPASGSRAA 60
VDPGVLTREV HSLSEYFSLL TRARRDADPP PGVASRQGDG HPRPPAEVLS PRDVFIAVKT 120
TRKFHRARLD LLFETWISRH KEMTFIFTDG EDEALAKLTG NVVLTNCSSA HSRQALSCKM 180
AVEYDRFIES GKKWFCHVDD DNYVNLRALL RLLASYPHTQ DVYIGKPSLD RPIQATERIS 240
EHKVRPVHFW FATGGAGFCI SRGLALKMGP WASGGHFMST AERIRLPDDC TIGYIVEALL 300
GVPLIRSGLF HSHLENLQQV PTTELHEQVT LSYGMFENKR NAVHIKGPFS VEADPSRFRS 360
VHCHLYPDTP WCPRSAIF
379Fasta Sequence
>O09010|Lfng|Mus musculus(Mouse)
MLQRCGRRLLLALVGALLACLLVLTADPPPTPMPAERGRRALRSLAGSSGGAPASGSRAAVDPGVLTREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHPRPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKLTGNVVLTNCSSAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPHTQDVYIGKPSLDRPIQATERISEHKVRPVHFWFATGGAGFCISRGLALKMGPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYGMFENKRNAVHIKGPFSVEADPSRFRSVHCHLYPDTPWCPRSAIF
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0328--Glycosyltransferase
KW-0333--Golgi apparatus
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR017374--Fringe
IPR003378--Fringe-like
|
| PROSITE |
|
| Pfam |
PF02434--Fringe
|
| Gene Ontology |
GO:1903561--C:extracellular vesicle
GO:0000139--C:Golgi membrane
GO:0030173--C:integral component of Golgi membrane
GO:0046872--F:metal ion binding
GO:0033829--F:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0007386--P:compartment pattern specification
GO:0007143--P:female meiotic division
GO:0002315--P:marginal zone B cell differentiation
GO:1902367--P:negative regulation of Notch signaling pathway involved in somitogenesis
GO:0001541--P:ovarian follicle development
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0032092--P:positive regulation of protein binding
GO:0008593--P:regulation of Notch signaling pathway
GO:0014807--P:regulation of somitogenesis
GO:0001756--P:somitogenesis
GO:0030217--P:T cell differentiation
|
