dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000412
Uniprot Accession O09005; DEGS1_MOUSE; Q8R4H3;
Genbank Protein ID NP_031879.1;
Genbank Nucleotide ID NM_007853.4;
Protein Name Sphingolipid delta(4)-desaturase DES1
Protein Synonyms/Alias Degenerative spermatocyte homolog 1;
Gene Name Degs1
Gene Synonyms/Alias Degs;Des1;Mdes;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
284RKIASEYYDDLPHYNPhosphoSitePlus22135298
Sequence
(Fasta)		MGSRVSREEF EWVYTDQPHA ARRKEILAKY PEIKSLMKPD HNLIWIVAMM LLVQLASFYL 60
VKDLDWKWVI FWSYVFGSCL NHSMTLAIHE ISHNFPFGHH KALWNRWFGM FANLSLGVPY 120
SISFKRYHMD HHRYLGADKI DVDIPTDFEG WFFCTTFRKF VWVILQPLFY AFRPLFINPK 180
PITYLEIINT VIQITFDIII YYVFGVKSLV YMLAATLLGL GLHPISGHFI AEHYMFLKGH 240
ETYSYYGPLN LLTFNVGYHN EHHDFPNVPG KNLPMVRKIA SEYYDDLPHY NSWIKVLYDF 300
VTDDTISPYS RMKRPPKGNE ILE 324
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0519--Myristate
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR031196--DES1
IPR011388--DES1/DES2
IPR005804--Fatty_acid_desaturase_dom
IPR013866--Sphingolipid_d4-desaturase_N
PROSITE
Pfam

PF00487--FA_desaturase
PF08557--Lipid_DES
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005739--C:mitochondrion
GO:0042284--F:sphingolipid delta-4 desaturase activity
GO:0046513--P:ceramide biosynthetic process
GO:0006633--P:fatty acid biosynthetic process
GO:0043065--P:positive regulation of apoptotic process