dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000411
Uniprot Accession O09000; NCOA3_MOUSE; Q9CRD5;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Nuclear receptor coactivator 3
Protein Synonyms/Alias
Gene Name Ncoa3
Gene Synonyms/Alias Aib1;Pcip;Rac3;Tram1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 32 (View all)
PositionPeptidesSourceReferences ( PMIDs )
215ILEDVNASPETRQRYdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 16381945; 23193290; 18846507; 19854140; 20531401;
261VTAPFPSSPESFITRdbPTM 3.0;PhosphoSitePlus;curated22028470; 16381945; 23193290; 22135298; 23984901; 25338131
498SPAAGAHSPMGPSGNdbPTM 3.0;PhosphoSitePlus20534466; 16381945; 23193290; 22135298
536SLLSTLSSPGPKLDNdbPTM 3.0;PhosphoSitePlus20534466; 16381945; 23193290; 22135298
544PGPKLDNSPNMNISQdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19144319; 16381945; 23193290; 19854140; 21183079; 21081558;
560SKVSGQDSKSPLGLYcurated25266776
562VSGQDSKSPLGLYCEdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 21659605; 16381945; 23193290; 19060867; 22135298;
628SSDDRGHSSLTNSPLPhosphoPep 2.019060867
629SDDRGHSSLTNSPLDdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298
633GHSSLTNSPLDPNCKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 19060867; 22135298; 22817900
645NCKDSSVSVTSPSGVPhosphoSitePlus22135298
648DSSVSVTSPSGVSSScurated25266776
654TSPSGVSSSTSGTVSPhosphoSitePlus22135298
661SSTSGTVSSTSNVHGPhosphoSitePlus22135298
687KLLQNGNSPAEVAKIcurated23984901; 25338131
713TASCGEGTTRQEQLScurated25266776; 23984901
714ASCGEGTTRQEQLSPcurated25266776
720TTRQEQLSPKKKENNdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated19144319; 16381945; 23193290; 22135298; 25266776; 21743459;
847PPYNRAVSLDSPVSVdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 16381945; 23193290; 17043108; 17242355; 18846507;
850NRAVSLDSPVSVGSGdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18846507; 19144319; 20531401; 20534466; 21183079; 21659605;
Sequence
(Fasta)		MSGLGESSLD PLAAESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA ELISANLSDI 60
DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD VSSTGQGVID KDSLGPLLLQ 120
ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ EDLVNTSVYS ILHEPRRKDF LNTYQNPQLM 180
EFLGLMRTRD KKAPYILIVR MLMKTHDILE DVNASPETRQ RYETMQCFAL SQPRAMLEEG 240
EDLQCCMICV ARRVTAPFPS SPESFITRHD LSGKVVNIDT NSLRSSMRPG FEDIIRRCIQ 300
RFFSLNDGQS WSQKRHYQEA YVHGHAETPV YRFSLADGTI VSAQTKSKLF RNPVTNDRHG 360
FISTHFLQRE QNGYRPNPIP QDKGIRPPAA GCGVSMSPNQ NVQMMGSRTY GVPDPSNTGQ 420
MGGARYGASS SVASLTPGQS LQSPSSYQNS SYGLSMSSPP HGSPGLGPNQ QNIMISPRNR 480
GSPKMASHQF SPAAGAHSPM GPSGNTGSHS FSSSSLSALQ AISEGVGTSL LSTLSSPGPK 540
LDNSPNMNIS QPSKVSGQDS KSPLGLYCEQ NPVESSVCQS NSRDPQVKKE SKESSGEVSE 600
TPRGPLESKG HKKLLQLLTC SSDDRGHSSL TNSPLDPNCK DSSVSVTSPS GVSSSTSGTV 660
SSTSNVHGSL LQEKHRILHK LLQNGNSPAE VAKITAEATG KDTSSTASCG EGTTRQEQLS 720
PKKKENNALL RYLLDRDDPS DVLAKELQPQ ADSGDSKLSQ CSCSTNPSSG QEKDPKIKTE 780
TNDEVSGDLD NLDAILGDLT SSDFYNNPTN GGHPGAKQQM FAGPSSLGLR SPQPVQSVRP 840
PYNRAVSLDS PVSVGSGPPV KNVSAFPGLP KQPILAGNPR MMDSQENYGA NMGPNRNVPV 900
NPTSSPGDWG LANSRASRME PLASSPLGRT GADYSATLPR PAMGGSVPTL PLRSNRLPGA 960
RPSLQQQQQQ QQQQQQQQQQ QQQQQQQMLQ MRTGEIPMGM GVNPYSPAVQ SNQPGSWPEG 1020
MLSMEQGPHG SQNRPLLRNS LDDLLGPPSN AEGQSDERAL LDQLHTFLSN TDATGLEEID 1080
RALGIPELVN QGQALESKQD VFQGQEAAVM MDQKAALYGQ TYPAQGPPLQ GGFNLQGQSP 1140
SFNSMMGQIS QQGSFPLQGM HPRAGLVRPR TNTPKQLRMQ LQQRLQGQQF LNQSRQALEM 1200
KMENPAGTAV MRPMMPQAFF NAQMAAQQKR ELMSHHLQQQ RMAMMMSQPQ PQAFSPPPNV 1260
TASPSMDGVL AGSAMPQAPP QQFPYPANYG MGQPPEPAFG RGSSPPSAMM SSRMGPSQNA 1320
MVQHPQPTPM YQPSDMKGWP SGNLARNGSF PQQQFAPQGN PAAYNMVHMN SSGGHLGQMA 1380
MTPMPMSGMP MGPDQKYC 1399
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
Interpro

IPR011598--bHLH_dom
IPR010011--DUF1518
IPR032565--DUF4927
IPR028818--NCOA3
IPR009110--Nuc_rcpt_coact
IPR014920--Nuc_rcpt_coact_Ncoa-typ
IPR017426--Nuclear_rcpt_coactivator
IPR000014--PAS
IPR013767--PAS_fold
IPR014935--SRC-1
IPR008955--Src1_rcpt_coact
PROSITE

PS50888--BHLH
PS50112--PAS
Pfam

PF07469--DUF1518
PF16279--DUF4927
PF08815--Nuc_rec_co-act
PF00989--PAS
PF08832--SRC-1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0003682--F:chromatin binding
GO:0004402--F:histone acetyltransferase activity
GO:0016922--F:ligand-dependent nuclear receptor binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257--F:nuclear hormone receptor binding
GO:0047485--F:protein N-terminus binding
GO:0003713--F:transcription coactivator activity
GO:0001135--F:transcription factor activity, RNA polymerase II transcription factor recruiting
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0071392--P:cellular response to estradiol stimulus
GO:0032870--P:cellular response to hormone stimulus
GO:0048589--P:developmental growth
GO:0016573--P:histone acetylation
GO:0060713--P:labyrinthine layer morphogenesis
GO:0060744--P:mammary gland branching involved in thelarche
GO:0035264--P:multicellular organism growth
GO:2000737--P:negative regulation of stem cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0045618--P:positive regulation of keratinocyte differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2001141--P:regulation of RNA biosynthetic process
GO:2000035--P:regulation of stem cell division
GO:2000036--P:regulation of stem cell population maintenance
GO:0072091--P:regulation of stem cell proliferation
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0060068--P:vagina development