dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000410
Uniprot Accession O08999; LTBP2_MOUSE; Q8C6W9;
Genbank Protein ID NP_038617.3;
Genbank Nucleotide ID NM_013589.3;
Protein Name Latent-transforming growth factor beta-binding protein 2
Protein Synonyms/Alias
Gene Name Ltbp2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 May play an integral structural role in elastic-fiber architectural organization and/or assembly. May be involved in the assembly, secretion and targeting of TGF- beta to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGF-beta. May have a structural role in the extra cellular matrix (ECM).
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
270PPPSRRLSQPWPLQQPhosphoSitePlus22135298
363NSCEKGDTTTLYSQGdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated17203969; 16381945; 23193290; 22135298; 19366988; 22817900
364SCEKGDTTTLYSQGGdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated17203969; 16381945; 23193290; 22135298; 19366988; 22817900
367KGDTTTLYSQGGHGHdbPTM 3.0;SysPTM 2.0;curated17203969; 16381945; 23193290; 19366988; 22817900
368GDTTTLYSQGGHGHDdbPTM 3.0;SysPTM 2.0;curated17203969; 16381945; 23193290; 19366988; 22817900
491DPVLEDNSVETRASHdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19367708; 16381945; 23193290; 21183079; 21081558; 19060867;
529PRPPPVLSRHYGLLGPhosphoSitePlus22135298
664QQGLCYRSLGSGTCTPhosphoSitePlus22135298
785DSRAVQITTSAPHLPdbPTM 3.0;PHOSIDA;PhosphoSitePlus19367708; 16381945; 23193290; 21081558; 22135298
786SRAVQITTSAPHLPAdbPTM 3.0;PHOSIDA;PhosphoSitePlus19367708; 16381945; 23193290; 21081558; 22135298
787RAVQITTSAPHLPARdbPTM 3.0;PHOSIDA;PhosphoSitePlus19367708; 16381945; 23193290; 21081558; 22135298
937VCSGGRCSNTEGSYHPhosphoSitePlus22135298
939SGGRCSNTEGSYHCEPhosphoSitePlus22135298
942RCSNTEGSYHCECDRPhosphoSitePlus22135298
943CSNTEGSYHCECDRGPhosphoSitePlus22135298
Sequence
(Fasta)		MRAPTTARCS GCIQRVRWRG FLPLVLAVLM GTSHAQRDSI GRYEPASRDA NRLWHPVGSH 60
PAAAAAKVYS LFREPDAPVP GLSPSEWNQP AQGNPGWLAE AEARRPPRTQ QLRRVQPPVQ 120
TRRSHPRGQQ QIAARAAPSV ARLETPQRPA AARRGRLTGR NVCGGQCCPG WTTSNSTNHC 180
IKPVCQPPCQ NRGSCSRPQV CICRSGFRGA RCEEVIPEEE FDPQNARPVP RRSVERAPGP 240
HRSSEARGSL VTRIQPLVPP PSPPPSRRLS QPWPLQQHSG PSRTVRRYPA TGANGQLMSN 300
ALPSGLELRD SSPQAAHVNH LSPPWGLNLT EKIKKIKVVF TPTICKQTCA RGRCANSCEK 360
GDTTTLYSQG GHGHDPKSGF RIYFCQIPCL NGGRCIGRDE CWCPANSTGK FCHLPVPQPD 420
REPAGRGSRH RTLLEGPLKQ STFTLPLSNQ LASVNPSLVK VQIHHPPEAS VQIHQVARVR 480
GELDPVLEDN SVETRASHRP HGNLGHSPWA SNSIPARAGE APRPPPVLSR HYGLLGQCYL 540
STVNGQCANP LGSLTSQEDC CGSVGTFWGV TSCAPCPPRQ EGPAFPVIEN GQLECPQGYK 600
RLNLSHCQDI NECLTLGLCK DSECVNTRGS YLCTCRPGLM LDPSRSRCVS DKAVSMQQGL 660
CYRSLGSGTC TLPLVHRITK QICCCSRVGK AWGSTCEQCP LPGTEAFREI CPAGHGYTYS 720
SSDIRLSMRK AEEEELASPL REQTEQSTAP PPGQAERQPL RAATATWIEA ETLPDKGDSR 780
AVQITTSAPH LPARVPGDAT GRPAPSLPGQ GIPESPAEEQ VIPSSDVLVT HSPPDFDPCF 840
AGASNICGPG TCVSLPNGYR CVCSPGYQLH PSQDYCTDDN ECMRNPCEGR GRCVNSVGSY 900
SCLCYPGYTL VTLGDTQECQ DIDECEQPGV CSGGRCSNTE GSYHCECDRG YIMVRKGHCQ 960
DINECRHPGT CPDGRCVNSP GSYTCLACEE GYVGQSGSCV DVNECLTPGI CTHGRCINME 1020
GSFRCSCEPG YEVTPDKKGC RDVDECASRA SCPTGLCLNT EGSFTCSACQ SGYWVNEDGT 1080
ACEDLDECAF PGVCPTGVCT NTVGSFSCKD CDQGYRPNPL GNRCEDVDEC EGPQSSCRGG 1140
ECKNTEGSYQ CLCHQGFQLV NGTMCEDVNE CVGEEHCAPH GECLNSLGSF FCLCAPGFAS 1200
AEGGTRCQDV DECAATDPCP GGHCVNTEGS FSCLCETASF QPSPDSGECL DIDECEDRED 1260
PVCGAWRCEN SPGSYRCILD CQPGFYVAPN GDCIDIDECA NDTVCGNHGF CDNTDGSFRC 1320
LCDQGFETSP SGWECVDVNE CELMMAVCGD ALCENVEGSF LCLCASDLEE YDAEEGHCRP 1380
RVAGAQRIPE VRTEDQAPSL IRMECYSEHN GGPPCSQILG QNSTQAECCC TQGARWGKAC 1440
APCPSEDSVE FSQLCPSGQG YIPVEGAWTF GQTMYTDADE CVLFGPALCQ NGRCSNIVPG 1500
YICLCNPGYH YDASSRKCQD HNECQDLACE NGECVNQEGS FHCLCNPPLT LDLSGQRCVN 1560
TTSSTEDFPD HDIHMDICWK KVTNDVCSQP LRGHHTTYTE CCCQDGEAWS QQCALCPPRS 1620
SEVYAQLCNV ARIEAERGAG IHFRPGYEYG PGLDDLPENL YGPDGAPFYN YLGPEDTAPE 1680
PPFSNPASQP GDNTPVLEPP LQPSELQPHY LASHSEPPAS FEGLQAEECG ILNGCENGRC 1740
VRVREGYTCD CFEGFQLDAP TLACVDVNEC EDLNGPARLC AHGHCENTEG SYRCHCSPGY 1800
VAEPGPPHCA AKE 1814
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0340--Growth factor binding
KW-0358--Heparin-binding
KW-0379--Hydroxylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR009030--Growth_fac_rcpt_N_dom
IPR017878--TB_dom
PROSITE

PS00070--ALDEHYDE_DEHYDR_CYS
PS00010--ASX_HYDROXYL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS51364--TB
Pfam

PF00008--EGF
PF07645--EGF_CA
PF00683--TB
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031012--C:extracellular matrix
GO:0005615--C:extracellular space
GO:0005509--F:calcium ion binding
GO:0008201--F:heparin binding
GO:0043206--P:extracellular fibril organization