dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000408
Uniprot Accession O08992; SDCB1_MOUSE; A2AKJ7; Q544P5;
Genbank Protein ID NP_001091697.1; NP_058087.2; XP_006538147.1;
Genbank Nucleotide ID NM_001098227.1; NM_016807.2; XM_006538084.2;
Protein Name Syntenin-1
Protein Synonyms/Alias Scaffold protein Pbp1;Syndecan-binding protein 1;
Gene Name Sdcbp
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
6--MSLYPSLEDLKVDdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19367708; 19854140; 20415495; 16381945; 23193290; 21081558;
22VIQAQTAYSANPASQPhosphoSitePlus22135298
57LYPELSQYMGLSLNEPhosphoSitePlus22135298
88GQLVARPSSVNYMVAcurated22817900; 25338131
89QLVARPSSVNYMVAPcurated22817900
92ARPSSVNYMVAPVTGdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated18515860; 16381945; 23193290; 22135298; 19366988; 22817900
216HVGFIFKSGKITSIVPhosphoSitePlus;curated22135298; 23684622
Sequence
(Fasta)		MSLYPSLEDL KVDKVIQAQT AYSANPASQA FVLVDASAAL PPDGNLYPKL YPELSQYMGL 60
SLNEAEICES MPMVSGAPAQ GQLVARPSSV NYMVAPVTGN DAGIRRAEIK QGIREVILCK 120
DQDGKIGLRL KSIDNGIFVQ LVQANSPASL VGLRFGDQVL QINGENCAGW SSDKAHKVLK 180
QAFGEKITMT IRDRPFERTV TMHKDSSGHV GFIFKSGKIT SIVKDSSAAR NGLLTDHHIC 240
EINGQNVIGL KDAQIADILS TAGTVVTITI MPTFIFEHII KRMAPSIMKS LMDHTIPEV 300
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR001478--PDZ
IPR030528--SDCBP
PROSITE

PS50106--PDZ
Pfam

PF00595--PDZ
Gene Ontology

GO:0072562--C:blood microparticle
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:1903561--C:extracellular vesicle
GO:0005895--C:interleukin-5 receptor complex
GO:0042470--C:melanosome
GO:0005886--C:plasma membrane
GO:0005109--F:frizzled binding
GO:0042802--F:identical protein binding
GO:0005137--F:interleukin-5 receptor binding
GO:0046982--F:protein heterodimerization activity
GO:0047485--F:protein N-terminus binding
GO:0045545--F:syndecan binding
GO:0030036--P:actin cytoskeleton organization
GO:1903543--P:positive regulation of exosomal secretion
GO:1903553--P:positive regulation of extracellular exosome assembly
GO:0042327--P:positive regulation of phosphorylation
GO:0007265--P:Ras protein signal transduction
GO:0007268--P:synaptic transmission