| Tag |
Content |
| dbPAF ID |
dbPAF-0000403 |
| Uniprot Accession |
O08967; CYH3_MOUSE; Q8CI93;
|
| Genbank Protein ID |
NP_035312.3;
|
| Genbank Nucleotide ID |
NM_011182.4;
|
| Protein Name |
Cytohesin-3 |
| Protein Synonyms/Alias |
ARF nucleotide-binding site opener 3;Protein ARNO3;General receptor of phosphoinositides 1;Grp1;PH, SEC7 and coiled-coil domain-containing protein 3;CLM3;SEC7 homolog C;mSec7-3; |
| Gene Name |
Cyth3 |
| Gene Synonyms/Alias |
Grp1;Pscd3; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP.Functional Description
Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MDEGGGGEGG SVPEDLSLEE REELLDIRRR KKELIDDIER LKYEIAEVMT EIDNLTSVEE 60
SKTTQRNKQI AMGRKKFNMD PKKGIQFLIE NDLLQSSPED VAQFLYKGEG LNKTVIGDYL 120
GERDDFNIKV LQAFVELHEF ADLNLVQALR QFLWSFRLPG EAQKIDRMME AFASRYCLCN 180
PGVFQSTDTC YVLSFAIIML NTSLHNHNVR DKPTAERFIT MNRGINEGGD LPEELLRNLY 240
ESIKNEPFKI PEDDGNDLTH TFFNPDREGW LLKLGGRVKT WKRRWFILTD NCLYYFEYTT 300
DKEPRGIIPL ENLSIREVED PRKPNCFELY NPSHKGQVIK ACKTEADGRV VEGNHVVYRI 360
SAPSPEEKEE WMKSIKASIS RDPFYDMLAT RKRRIANKK
Fasta Sequence
>O08967|Cyth3|Mus musculus(Mouse)
MDEGGGGEGGSVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDDFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFITMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
|
| Keyword |
KW-0002--3D-structure
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0446--Lipid-binding
KW-0472--Membrane
KW-1185--Reference proteome
|
| Interpro |
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR023394--Sec7_alpha_orthog
IPR000904--Sec7_dom
|
| PROSITE |
PS50003--PH_DOMAIN
PS50190--SEC7
|
| Pfam |
PF00169--PH
PF01369--Sec7
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0090162--P:establishment of epithelial cell polarity
GO:0048193--P:Golgi vesicle transport
GO:0045785--P:positive regulation of cell adhesion
GO:0043547--P:positive regulation of GTPase activity
GO:0032012--P:regulation of ARF protein signal transduction
|
