dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000401
Uniprot Accession O08962; KCNH2_RAT; O08720;
Genbank Protein ID NP_446401.1;
Genbank Nucleotide ID NM_053949.1;
Protein Name Potassium voltage-gated channel subfamily H member 2
Protein Synonyms/Alias Ether-a-go-go-related gene potassium channel 1;ERG-1;Eag-related protein 1;Ether-a-go-go-related protein 1;RERG;r-ERG;Voltage-gated potassium channel subunit Kv11.1;
Gene Name Kcnh2
Gene Synonyms/Alias Erg;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
285CASVRRASSADDIEAPhosphoSitePlus;UniProt22135298; 22673903
286ASVRRASSADDIEAMPhosphoSitePlus;UniProt22135298; 22673903
353KGDPFLASPTSDREIPhosphoSitePlus;UniProt22135298; 22673903
613GPSIKDKYVTALYFTdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 22817900
615SIKDKYVTALYFTFSPhosphoSitePlus;SysPTM 2.0;curated22135298; 16641100; 19366988; 22817900
620YVTALYFTFSSLTSVPhosphoSitePlus;SysPTM 2.0;curated22135298; 16641100; 19366988; 22817900
622TALYFTFSSLTSVGFPhosphoSitePlus;SysPTM 2.0;curated22135298; 16641100; 19366988; 22817900
623ALYFTFSSLTSVGFGPhosphoSitePlus;SysPTM 2.0;curated22135298; 16641100; 19366988; 22817900
Sequence
(Fasta)		MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM 60
QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG 120
AVIMFILNFE VVMEKDMVGS PAHDTNHRGP STSWLASGRA KTFRLKLPAL LALTARESPM 180
RTGSTGSPGA PGAVVVDVDL TPAAPSSESL ALDEVSAMDN HVAGLGPAEE RRALVGPASA 240
SPVASIPGPH PSPRAQSLNP DASGSSCSLA RTRSRESCAS VRRASSADDI EAMRAGALPL 300
PPRHASTGAM HPLRSGLLNS TSDSDLVRYR TISKIPQITL NFVDLKGDPF LASPTSDREI 360
IAPKIKERTH NVTEKVTQVL SLGADVLPEY KLQAPRIHRW TILHYSPFKA VWDWLILLLV 420
IYTAVFTPYS AAFLLKETED GSQAPDCGYA CQPLAVVDLL VDIMFIVDIL INFRTTYVNA 480
NEEVVSHPGR IAVHYFKGWF LIDMVAAIPF DLLIFGSGSE ELIGLLKTAR LLRLVRVARK 540
LDRYSEYGAA VLFLLMCTFA LIAHWLACIW YAIGNMEQPH MDSHIGWLHN LGDQIGKPYN 600
SSGLGGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNSEK IFSICVMLIG SLMYASIFGN 660
VSAIIQRLYS GTARYHTQML RVREFIRFHQ IPNPLRQRLE EYFQHAWSYT NGIDMNAVLK 720
GFPECLQADI CLHLNRSLLQ HCKPFRGATK GCLRALAMKF KTTHAPPGDT LVHAGDLLTA 780
LYFISRGSIE ILRGDVVVAI LGKNDIFGEP LNLYARPGKS NGDVRALTYC DLHKIHRDDL 840
LEVLDMYPEF SDHFWSSLEI TFNLRDTNMI PGSPSSAELE SGFNRQRKRK LSFRRRTDKD 900
TEQPGEVSAL GQGPARVGPG PSCRGQPGGP WGESPSSGPS SPESSEDEGP GRSSSPLRLV 960
PFSSPRPPGD SPGGEPLTED GEKSSDTCNP LSGAFSGVSN IFSFWGDSRG RQYQELPRCP 1020
APAPSLLNIP LSSPGRRSRG DVESRLDALQ RQLNRLETRL SADMATVLQL LQRQMTLVPP 1080
AYSAVTTPGP GPTSTSPLLP VGPVPTLTLD SLSQVSQFVA FEELPAGAPE LPQDGPTRRL 1140
SLPGQLGALT SQPLHRHGSD PGS 1164
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0630--Potassium
KW-0631--Potassium channel
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0851--Voltage-gated channel
Interpro

IPR018490--cNMP-bd-like
IPR000595--cNMP-bd_dom
IPR005821--Ion_trans_dom
IPR003938--K_chnl_volt-dep_EAG/ELK/ERG
IPR003967--K_chnl_volt-dep_ERG
IPR001610--PAC
IPR000014--PAS
IPR000700--PAS-assoc_C
IPR014710--RmlC-like_jellyroll
PROSITE

PS50042--CNMP_BINDING_3
PS50113--PAC
PS50112--PAS
Pfam

PF00027--cNMP_binding
PF00520--Ion_trans
PF13426--PAS_9
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005242--F:inward rectifier potassium channel activity
GO:0005216--F:ion channel activity
GO:0000155--F:phosphorelay sensor kinase activity
GO:0005267--F:potassium channel activity
GO:0097110--F:scaffold protein binding
GO:0005249--F:voltage-gated potassium channel activity
GO:0007420--P:brain development
GO:0071805--P:potassium ion transmembrane transport
GO:0006813--P:potassium ion transport
GO:0051291--P:protein heterooligomerization
GO:0086091--P:regulation of heart rate by cardiac conduction
GO:0042391--P:regulation of membrane potential
GO:0021510--P:spinal cord development