| Tag |
Content |
| dbPAF ID |
dbPAF-0000399 |
| Uniprot Accession |
O08934; UNC4_MOUSE; P70457; Q78DU3;
|
| Genbank Protein ID |
NP_038730.1;
|
| Genbank Nucleotide ID |
NM_013702.3;
|
| Protein Name |
Homeobox protein unc-4 homolog |
| Protein Synonyms/Alias |
Homeobox protein Uncx4.1; |
| Gene Name |
Uncx |
| Gene Synonyms/Alias |
Uncx4.1; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions.Functional Description
Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 341 | VESLLSDSPPRRKAT | curated | 23384938 |
|
Sequence
(Fasta) | MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAAAA ASVPFSIDGL 60
LSGSCAAAAA SVVNPTPLLP AACGVAGESQ PFKLADSGDP DKESPGCKRR RTRTNFTGWQ 120
LEELEKAFNE SHYPDVFMRE ALALRLDLVE SRVQVWFQNR RAKWRKKENT KKGPGRPAHN 180
SHPTTCSGEP MDPEEIARKE LEKMEKKKRK HEKKLLKSQS RHLHSPGGLS LHSAPSSDSD 240
SGGGGLSPEP PEPPPPTAAA KGPGAHGSGI AGSAPVPPGE PPAPGTCDPA FYPSQRSGAG 300
SQPRLGRPAD KDTVPCGPGA AATAGLPKAS PFSVESLLSD SPPRRKATPA NAAATAGLDF 360
TPGLPCAPRT LIGKGHFLLY PITQPLGFLV PQAALKGGAG PELVPKDAPP APPAPPAPPA 420
QASFGTFPGP GGAADPAFAR RSPEVVASPG PPAPASFRDL TAAAAESGAG DCADVGTVCP 480
AASPPPPLET SPGPGPRAPS PPGEPATCGA AEPGAATGPS PPEGEEVDMD
531Fasta Sequence
>O08934|Uncx|Mus musculus(Mouse)
MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAAAAASVPFSIDGLLSGSCAAAAASVVNPTPLLPAACGVAGESQPFKLADSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQSRHLHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPTAAAKGPGAHGSGIAGSAPVPPGEPPAPGTCDPAFYPSQRSGAGSQPRLGRPADKDTVPCGPGAAATAGLPKASPFSVESLLSDSPPRRKATPANAAATAGLDFTPGLPCAPRTLIGKGHFLLYPITQPLGFLVPQAALKGGAGPELVPKDAPPAPPAPPAPPAQASFGTFPGPGGAADPAFARRSPEVVASPGPPAPASFRDLTAAAAESGAGDCADVGTVCPAASPPPPLETSPGPGPRAPSPPGEPATCGAAEPGAATGPSPPEGEEVDMD
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
|
| PROSITE |
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
|
| Pfam |
PF00046--Homeobox
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0001502--P:cartilage condensation
GO:0035726--P:common myeloid progenitor cell proliferation
GO:0021516--P:dorsal spinal cord development
GO:0021889--P:olfactory bulb interneuron differentiation
GO:0007389--P:pattern specification process
GO:0045595--P:regulation of cell differentiation
GO:0010468--P:regulation of gene expression
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
